摘要
目的 研究 L ASIK手术对角膜内皮细胞的影响。方法 5 1例 96眼近视眼患者进行 L ASIK治疗 ,等效球镜度数 - 1.5 0 D～ - 15 .75 D(- 6 .92± 3.43D) ,并按照准分子激光切削后角膜基质床的厚度分别分成三组 : .2 0 0～ 2 5 0μm ; .2 5 0～ 30 0μm; .30 0μm以上。各组患眼于术前和术后 3个月进行角膜内皮镜检查 ,观察角膜内皮细胞形态和内皮细胞密度。结果 L ASIK手术前后角膜内皮细胞形态结构无明显改变 ,术前、术后角膜内皮细胞密度分别为 316 5± 32 4/ mm2 和 315 1± 30 5 / mm2 ,配对 t检验 ,无显著性差异 (P >0 .0 5 )。按照激光切削后角膜基质床的厚度分成的三组术前、术后角膜内皮细胞密度也没有出现显著性改变 (P >0 .0 5 )。结论 L ASIK术后早期不会损伤角膜内皮 ,不会造成中央部角膜内皮细胞密度降低和细胞形态结构的改变 ,其对角膜内皮细胞的远期影响有待进一步的观察。
Objective To study the effect of LASIK on the human corneal endothelium.Methods Ninety-six eyes from fifty-one patients underwent LASIK for myopia or astigmatism,ranging from -1.50D～-15.75D (-6.92D±3.43D).Using a non-contact endothelial specular microscope (TOPCON SP2000),corneal endothelium was examined before LASIK and three months after the operation.According to the stroma depth after the ablation of excimer laser,eyes were divided into three groups:Group Ⅰ:eyes were 200～250μm,Group Ⅱ:eyes were 250～300μm;Groupe Ⅲ:eyes were 300μm and above.A comparative study was done among them.Results There were no significant morphological changes between before and after LASIK procedures.The mean preoperative and postoperative endothelial cell density was 3165±324 cells/mm 2 and 3151±305 cells/mm 2,respectively.There was no statistical significant between them (P>0 05) Compared with preoperative endothelium density,endothelium density in all three groups did not have statistical significant changes.No statistical significant correlation was found between the endothelium changes and the stroma depth after ablation.Conclusion LASIK does not significant reduce the endothelial cell count.As a method for correction of refractive errors,it is safe for corneal endothelium.It is necessary to perform a long-term follow-up of the endothelium after LASIK.
出处
《临床眼科杂志》
2001年第1期28-30,共3页
Journal of Clinical Ophthalmology
