摘要
目的 探讨非小细胞肺癌患者中N1的临床意义及与N0和N2的异同。方法 以 1982年 1月～ 1994年 12月我院 138例行根治性手术N1期NSCLC患者为研究对象 ,根据肺癌淋巴结分布图将N1分为叶内N1与叶外N2两亚组 ,与同期N0期 30 7例、N2期 176例行根治性手术NSCLC患者作比较 ,分析术后五年生存率。结果 138例N1期NSCLC患者五年生存率为 30 4% ,叶内N1与叶外N2两亚组五年生存率有显著性差别 (5 0 3 %比 2 6 5 % ,P =0 0 0 1) ,且叶内N1亚组与N0期五年生存率相似 (5 1 4%比 5 0 3 % ) ,而叶外N1亚组与单一区域N2期五年生存率相似 (2 6 5 %比2 3 5 % )。结论 N1分为二亚组 ,叶内N1亚组与N0期特性相似 。
Objective To investigate the prognostic significance of N1 stage in non small cell lung cancer (NSCLC) by comparing is survival with N0 and N2 stages. Methods From Jan. 1982 to Dec. 1994, 138 NSCLC patients with surgical pathological N1 stage had received complete mediastinal lymph node dissection. Two subgroups of N1 node were identified by using New Regional Lymph Node Classification for Lung Cancer Staging. Their prognostic significances were tested and 5 year survival rates were compared with those of surgical pathological N0 (307 cases) and N2 (176 cases) patients received radical operation during the same period. Results The overall 5 year suvival rate of N1 patients was 30 4 %. five year survival was significantly better when N1 involvement was intralobar as compared with extralobar involvement, 50 3 % versus 26 5 % ( P= 0 001). Intralobar N1 5 year survival was similar to that of N0 (51 4 % vs 50 3 %), and extralobar N1 5 year survival was similar to that of N2 with singl focus (26 5 % vs 23 5 %). Conclusion N1 stage in NSCLC is a compound with two subgroups; the prognostic significance of intralobar subgroup is related to N0 stage and extralobar subgroup is related to that of single focus N2.
出处
《肿瘤》
CAS
CSCD
北大核心
2001年第2期117-119,共3页
Tumor
