摘要
目的 探讨Ⅲ期N2非小细胞肺癌 (NSCLC)患者外科治疗的疗效及影响预后的因素。方法 回顾性分析 1982～ 1996年手术治疗的 2 6 6例Ⅲ期N2NSCLC患者的 5年生存率 ,与同期手术的N0、N1患者做比较 ,用Cox模型分析病理分型、淋巴结转移数目、淋巴结转移区域、手术方式、T状态、手术性质等对N2的NSCLC患者预后的影响。结果 2 6 6例Ⅲ期N2的NSCLC患者的 5年生存率为17.3% ,明显低于同期N0、N1患者的 5年生存率 (5 1.4 %和 30 .4 % ) ,淋巴结转移数目、淋巴结转移区域、T状态、手术性质为影响预后的重要因素。结论 对单区域纵隔淋巴结转移且估计能完全切除的Ⅲ期N2 (特别是T1)NSCLC应采取以手术为主的综合治疗。
Objective To study the survival and prognostic factors of stage Ⅲ N2 non-small cell lung cancer (NSCLC) after surgical treatment. Methods 266 patients with stage Ⅲ N2 NSCLC underwent operation from 1982 to 1996, with the 5-year survival rate compared with those of stage N0 and N1 patients who received operation in the same period. Histological classification, number of positive nodes, location and extent of mediastinal lymph node involvement, T primary tumor status, complete or incomplete operation, the procedure of operation were univariately and multivariately analyzed to determine their impact on the 5-year survival. Results The 5-year survival rate of patients with stage Ⅲ N2 non- small lung cancer after surgical treatment was 17.3%, which was significant lower than those with N0(51.4%) and N1(30.4%). Four prognostic factors significantly influenced the outcome: number of positive nodes, location and extent of mediastinal lymph node involvement, T primary tumor status and complete resection of the tumor. Conclusion Patients with stage Ⅲ N2 NSCLC are candidates for surgical treatment if they have evidence of limited mediastinal lymph node metastasis and prospects of complete resection.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2002年第6期605-607,共3页
Chinese Journal of Oncology
