摘要
利用离体灌注肾（ＩＰＫ）技术，观察了冬虫夏草（虫草）对肾脏的直接作用。结果表明，虫草的作用与其浓度有密切关系；当虫草液浓度为０．５ｇ／Ｌ时，能明显增加实验组的菊糖清除率，降低其血管阻力；同时虫草实验组的钠钾离子转运量明显增加；１．０ｇ／Ｌ的虫草则对菊糖清除率影响不明显，而血管阻力呈降低趋势。此外，虫草实验络的乳酸脱氢酶释放率低于对照组。而其葡萄糖异生能力明显优于对照组，肾皮质匀浆中ＭＤＡ含量亦呈减少的超过。说明虫草除去能明显影响肾血流动力学外．还能改善肾组织能量代谢，减轻细胞的损伤。
he object of this investigation was totest the
effects of CS on the isolated per-fused rat kidney(IPK). It could increase in-ulin clearance,
decrease resistance of renalvessels, improve the net reabsorption ofsodium and
potassium,and enhance the netglucose production , but reduce the release oflactic
dehydrogenase. It was concluded thatCS could not only change the renal hemody-namics, but
also improve the energymetabolism and decrease the cellular injury.
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
1995年第1期21-24,共4页
Chinese Journal of Nephrology,Dialysis & Transplantation
关键词
冬虫夏草
离体灌注肾
肾缺血
再灌注损伤
Cordyceps
Scinensis
isolated perfused kidney
hemodynamics
energy metabolism
