摘要
恒速iv乌头碱7.48mg/L·min^(-1)可引起小鼠多种心律失常。牛磺酸100mg/kg iv或奎尼丁5mg/kg iv分别可使心律失常发生时间推迟,乌头碱用量增加,与对照组比较有显著差别。牛磺酸50mg/kg iv或奎尼丁2.5mg/kg vi不能对抗乌头碱引起的心律失常,如两药合用,则可降低室颤的发生率,死亡时间亦推迟。实验提示:牛磺酸、奎尼丁及两药联合应用,有较好抗乌头碱心律失常作用。
The constant iv. of aconitine can induce the varied arrhythmias in mice. Taurine 100mg/kg iv. or Quinidine 5 mg/kg iv. can delays the onset time of arrhythmias, and increases the dose of aconitine, respectively .But no effects were seen in mice pretreated with taurine 50mg/kg or quinidine 2.5mg/kg. However their combination can significantly decrease the incident of ventricular fibrillation and delay the onset time of death. Our results suggested that taurine, quinidine and their combination are effective on arrhythmias induced by aconitine in mice.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1991年第3期194-197,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目
