摘要
甲基莲心碱（Ｎｅｆ）ｉｇ抑制大鼠血栓形成，单用Ｎｅｆ及与牛磺酸（Ｔａｕ）合用抑制率分别为５３．３１％和７４．３０％；对ＡＤＰ、胶原、凝血酶诱导的血小板聚集抑制率，Ｎｅｆ及Ｎｅｆ＋Ｔａｕ分别为５５．８％和７３．４％，４３．４５％和５９．３％，６５．３３％和７８．５％。两药对血浆纤维蛋白原、优球蛋白溶解时间均无明显影响。Ｎｅｆ能有效抑制ＡＤＰ诱导的血小板ＴＸＡ２释放，与Ｔａｕ合用抑制作用增强，而对血浆ＰＧＩ２含量无作用，Ｎｅｆ在ｉｖ后３０ｍｉｎ内对大鼠血清总胆固醇含量亦无影响，但与Ｔａｕ合用后能降低血清总胆固醇水平。
S The effects of neferineNef),
taurine(Tau) and Nef+Tau on platelet aggrega-tion and generation of
thrombosis were investigated in rats, Usomg turbidimetry Nef and Tau
were found to inhibit platelet aggregation induced by adenosine
diphosphate (ADP),collagen or thrombin.Both drugs reducde the wet
weight of experimeental thrombosis.Bit the drugs showed no obvious
dffect on fibrinogen content and euglobulin lysis time, Thromboxane
A2(TXA2 )production induced by ADP and prostacyclin(PGI2 ) were
studied by enzyme immunoassay in rats. TXA2 generation in platelet
rich plasma from rats treated with Nef and Nef+Tau obviously
decreased. While the plasma PGI2 was not affected, Nef+Tau iv in 30
min significantbly decreased the level of total cholesterin in serum.
The results suggest that Nef has inhibitory effect on platelet
aggregation and thrombosis formation.The combination of both drugs
was found to be more potent than either one alone,The mechanism may
be related to its reduction of TXA2 formation.
出处
《药学学报》
CAS
CSCD
北大核心
1995年第7期486-490,共5页
Acta Pharmaceutica Sinica
关键词
甲基莲心碱
牛磺酸
血栓形成
血栓素A2
前列环素
Neferine
Taurine
Thrombosis
Thromboxane A2
Prostacyclin Department of
Pharmacology , Hengyang Medical College , Hengyang 421001
