摘要
目的 研究电离辐射对伤口中性粒细胞数量和部分功能的影响及康复新的作用。方法 从置入大鼠背部的海绵中收集中性粒细胞 ,测定其数量和吞噬、运动功能变化。结果 伤后 2 4～ 48h ,4、6、8Gy全身照射复合创伤组 ,伤口白细胞和中性粒细胞数量均显著低于单创组 ,且中性粒细胞吞噬功能和运动功能也降低。康复新对单纯创伤、6Gy放射复合伤组伤口中性粒细胞数量和功能有明显的提高。结论 创伤愈合早期 ,伤口中性粒细胞数量和功能的下降是全身照射引起愈合延迟的原因之一 ;
Objective To study the effects of systemic irradiation and conglutinant drug W 11 a 12 on the number and some functions of wound nentrophils (Neu). Methods Wound Neu was collected from sponges which were implanted in rat's dorsum incision. The number of Neu, as well as the phagocytic function and motility of wound Neu were measured. Results After 4,6,8 Gy systemic irradiation, the number of white blood cells and Neu in wound, as well as the phagocytic function and chemotactic motility of wound Neu, were significantly decreased at 24 h, 48 h after wounding. W 11 a 12 markedly increased the number of wound Neu, improved the phagocytic function and chemotactic motility of wound Neu at 24 h, 48 h after wounding despite the rats were radiated or not. Conclusion The results indicated that the decreased number and function of wound Neu in the early stage of wound healing contributed to the impairment of repair after systemic irradiation. W 11 a 12 accelerated normal and irradiation impaired wound healing partly by increasing the number of wound Neu and improving the Neu function.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2001年第3期287-289,共3页
Journal of Third Military Medical University
基金
国家"973"重点基础研究资助项目! (G1 9990 542 0 5)
重庆市科委院士基金资助项目! (98-50 81 )
