摘要
目的 探讨中国汉族人群分裂样精神病患者与 5 -HT2A受体基因T10 2 C多态性之间的关系。方法 采用AmP -RFLP方法 ,检测分裂样精神病患者和对照组的 5 -HT2A受体基因频率分布。结果 分裂样精神症患者 5 -HT2A受体基因型频率、等位基因频率与对照组无明显差异 ,但女性分裂样精神病患者A2 A2 基因型频率、A2 等位基因频率明显低于对照组 ,有精神病家族史分裂样精神病患者A1A2 基因型频率明显高于对照组。结论 本实验结果提示 ,5 -HT2A受体基因多态性与女性分裂样精神病及有精神病家族史的分裂样精神病患者密切相关 ,A1等位基因可能是分裂样精神病发病的风险基因之一。
Objective To assess the association between the gene polymorphism of the serotonin 2A receptor and schizophreniform psychosis.Methods The association between gene polymorphism of serotonin 2A receptor and schizophreniform psychosis was determined with amplification restriction fragment length polymorphism technique in healthy persons and 140 schizophreniform psychosis patients in Jiangsu,China.Results The frequency of A 2A 2 gene type of 5-HT 2A receptor gene polymorphism and A 2 allele was lower in the female schizophreniform psychosis than in the healty group,and the frequency of A 1A 2 gene type was higher in the familial schizophreniform psychosis than in the healthy group.Conclusions These results indicate that there is a positive asscociation between the variation of serotonin 2A receptor gene and female schizophreniform psychosis and familial schizophreniform psychosis.
出处
《四川精神卫生》
2001年第1期1-3,共3页
Sichuan Mental Health
