摘要
用同位素配基结合技术测定了双相情感性和分裂情感性精神病患者血小板５－ＨＴ２Ａ受体结合力。结果提示患者血小板５－ＨＴ２Ａ受体结合力增高与有自杀企图或自杀行为等症状有关。锂盐治疗效应可能与增加５－ＨＴ能神经功能有关。
5-HT receptors were studied by using 125 I lysergic acid diethylamide ( 125 I-LSD)as a ligand in the platelets of hospitalized bipolar and schizoaffective patients during a drug-free baseline period and after chronic treatment with Lithium.Suicidal,but not nonsuicidal, schizoaffective and biopdarpatients had significantly increased platelet 5-HT 2A receptors when compared to normal controls.Lithium treatment caused a signficant lncrease in the number of platelet 5-HT 2A receptors. Increased platelet 5-HT 2A receptors may be associated with suicidal behavior but not with the difference whether the illness is bipolar or schizoaffective.The therapeutic effect of lithium may be related to an enhancement of serotonergic function due to increased 5-HT 2A receptors.
出处
《徐州医学院学报》
CAS
1996年第3期248-251,共4页
Acta Academiae Medicinae Xuzhou
