摘要
目的 :探讨中国汉族人群难治性抑郁症患者与 5 羟色胺 2A(5 HT2A)受体基因的T10 2C多态性之间的关系。 方法 :抽取 79例难治性抑郁症患者作研究 ,以 10 2名正常人作对照。应用聚合酶链式反应 (PCR)扩增技术及限制性片段长度多态性 (RFLP)分别测定所有研究对象的 5 HT2A受体基因的基因型和等位基因。 结果 :5 HT2A受体基因的 3种基因型 (A1/A1,A1/A2和A2 /A2 )在难治性抑郁症组的分布分别为 31.6 %、5 4 .4 %和 13.9% ,在对照组分别为 2 9.4 %、4 5 .1%和 2 5 .5 % ,两组间差异无显著性。 结论 :5 HT2A受体基因的T10 2C多态性与难治性抑郁症之间无显著关联。
Objective:To explore the relationship between the treatment and the T102C polymorphisms of 5-HT 2A receptor gene in Han peoples with refractory depression. Method:The genotype and allelomorph of 5-HT 2A receptor gene in blood cell were examined with PCR-RFLP in 79 refractory depression patients and 102 controls respectively. Results:The frequencies of three T102C genotype of 5-HT 2A receptor gene (A1/A1,A1/A2 and A2/A2) were 31.6%, 54.4% and 13.9% respectively in the patients and 29.4%,45.1% and 25.5% in the controls.There was no significant difference between two groups. Conclusion:There was no significant association between the T102C polymorphisms of 5-HT 2A receptor gene and retractory depression.
出处
《临床精神医学杂志》
2004年第3期129-130,共2页
Journal of Clinical Psychiatry
基金
上海市卫生局青年科研基金 (项目号 0 14Y15 )
