摘要
目的 探讨Alzheimer病 (Alzheimerdisease ,AD)患者的载脂蛋白E(apolipoproteinE ,APOE)基因的分布 ,及其相关性 .方法 利用聚合酶链式反应 -限制性片段长度多态性 (PCR -RFLP)技术对AD患者和相应健康对照的APOE基因进行分型 ,从而进行AD与APOE等位基因多态性的关联分析 .结果 AD病人APOE等位基因 .ε4占 2 0 .74% ,明显高于正常人对照组的 7.6 4% ,而ε3则占 6 4.6 3% ,低于正常人对照组的 84.12 % .结论 APOE等位基因中 ,ε4可能为AD的易患因子 。
Objective To study the distribution of Apo E gene in patients with Alzheimer desease, and analyse the relation between them . Methods ApoE genotyes of patients with Alzheimer desease and age-matched healthy controls were determined by using the polymerphism technique,subsequently to require the ralation between ApoE allele and AD . Results ApoE ε4 allele of patients with AD was 20.4%,which obviously was higher than 7.5% of cotrols, but ε3 allele of patients with AD was 64.8%, which was lower than 83.2% of cotrols.Conclusions In ApoE allele, ε4 allele is a genetic suscetible factor in AD,and ε3 allele is a protection factor.
出处
《现代临床医学生物工程学杂志》
2001年第1期9-11,共3页
Journal of Modern Clinical Medical Bioengineering
