摘要
目的:建立阿尔茨海默病(AD)的个体健康危险因素的评价模型,预测个体发生阿尔茨海默病的风险。方法:通过文献检索的方法,收集阿尔茨海默病的危险因素、病例对照的研究资料,并用RevMan软件对这些文献进行Meta分析,将各研究的危险因素与阿尔茨海默病的比值比(OR)进行合并,以合并的OR值为基础建立危险分数表,从而建立危险因素评价模型。结果:建立了危险分数表,将表中所列有关分数相加得出了组合危险分数,并借此预测其发病危险。结论:运用该模型可对个体未来发生阿尔茨海默病的危险进行预测。
Objective： To establish an individual health risk appraisal model of Alzheimer＇s disease （AD） so to predict the risk of AD in the future. Methods： The results of case--control studies on risk factors of AD in China published domestically and abroad were collected through retrieval of literatures. Pooled odds ratio （OR） of risk factors for AD were estimated using software for recta--analysis to enable the risk factors be converted into risk fractions by statistical models. Results： An individ- ual health risk appraisal model of AD was established and the related risk scores were added to obtain a combined risk score to predict the individuaP s risk of AD. Conclusion： The model can be applied to forecast the risk of AD of individual in the future.
出处
《江苏预防医学》
CAS
2010年第1期18-21,共4页
Jiangsu Journal of Preventive Medicine
关键词
阿尔茨海默病
风险预测
循证研究
Alzheimer＇s disease
risk prediction
evidence--based study
