摘要
目的 :探讨缺锌与补锌对大鼠烧伤早期肠粘膜通透性的影响。方法 :1个月龄大鼠进食低锌饲料 (含锌量 :1.6 μg·g-1) 1周造成缺锌模型 ,2 0 %深Ⅱ度烫伤后改饲 3种不同含锌饲料 (含锌量分别为 :1.6、2 4.7和 2 86 .9μg·g-1)。同时设 1组大鼠烫伤前后均进食正常含锌饲料 (含锌量 :2 4.7μg·g-1) ,做对照组。在伤前 1天与伤后第 1天以甘露醇、乳果糖混合溶液灌胃 ,气相色谱法测定二者在尿中的含量和比例反映肠粘膜通透性的大小。结果 :伤前进食低锌饲料的大鼠尿中乳果糖 /甘露醇之比(0 .2 370± 0 .0 10 5 )显著高于对照组 (0 .12 0 2± 0 .0 146 ) ,主要由尿中乳果糖含量较高引起 ;伤后改饲含锌饲料使尿中甘露醇、乳果糖的含量、比例均降低 ,尤以改饲高锌饲料组效果显著 (0 .170 4± 0 .0 5 6 5 )。结论 :锌营养状态影响肠粘膜通透性 ,补锌可使烧伤后升高的肠通透性下降。
Objective:To investigate the effect of zinc supplements on gut mucosal permeability in zinc dificient rats after burns.[WT5HZ]Methods:Weanling rats were pair-fed zinc deficient diets(zinc content:1.6 μg·g -1 )for one week to induce zinc deficient status,then partial thickness of 20% TBSA was made.Then the rats were divided into three groups fed on chows different in zinc contents.Zinc contents were 1.6 μg·g -1 ,24.7 μg·g -1 ,286.9 μg·g -1 respectively.A group of rats fed normal zinc content(24.7 μg·g -1 )diets before and after scalds was designed as control.Lactose(L) and mannitol(M) were force-fed one day before and one day after scalds were made.The amounts of L and M as well as the ratio of L/M in urine were detected to reflect the permeability of gut mucosa. [WT5HZ]Results:The ratio of L/M was higher in zinc deficient rats (0.2 370±0.0 105) than that in control group (0.1 202±0.0 146)before scald.It was resulted from higher concentration of L in urine of the former.The amounts of L and M in urine were decreased to different extent after different amounts of zinc were supplemented.It was more evident in the group fed high zinc content chows(0.1 704±0.0 565).Conclusion:The nutritional status of zinc has some effects on the permeability of gut mucosa.To supplement zinc after major burns could decrease the increased permeability of intestinal mucosa.
出处
《西北国防医学杂志》
CAS
2001年第1期10-12,共3页
Medical Journal of National Defending Forces in Northwest China
基金
全军"九五"攻关课题基金资助项目! (96L0 43 )
