摘要
目的 探讨烧伤后是否存在“肠源性高代谢”。方法 在建立严重烧伤加清洁肠道动物模型基础上，将８８只Ｗｉｓｔａｒ大鼠随机分为烧伤对照（Ｂ）组和烧伤加清洁肠道（Ｄ）组。观察了大鼠伤后０－１０ ｄ静息能量消耗（ＲＥＥ）的变化，同时检测了伤后 １、３、５、７、１０ ｄ血中内毒素、肿瘤坏死因子（ＴＮＦ）和白细胞介素１（ＩＬ－１）的含量，并进行相关分析。结果 烧伤后两组大鼠的ＲＥＥ、ＴＮＦ、内毒素和ＩＬ－１均明显高于伤前。两组相比，Ｄ组的ＲＥＥ、ＴＮＦ内毒素和ＩＬ－１较Ｂ组均有不同程度的降低。相关分析显示，ＲＥＥ同内毒素、ＴＮＦ和 ＩＬ－１呈显著正相关（ｒ１＝０７７，Ｐ＜０．０５： ｒ２＝０８１，Ｐ＜０．０５；ｒ３＝０．０９，Ｐ＜０．０１）。结论 清洁肠道可降低烧伤大鼠高代谢反应，大鼠血中炎症介质的含量也下降，提示烧伤后存在肠源性高代谢。
Objective To explore whether postburn enterogenic hypermetabolism exists. Methods Eighty - eight Wistar rats inflicted by 30% TBSA Ⅲ degree burns were randomly divided into two groups ． i, e. burn (B ) and burn with gut decontamination (D ) groups. The change in resting energy expenditure (REE ) was obser-ved during 0 to 10 postburn day(PBDs) in rats. The plasma contents of lipopolysaccharide (LPS), tumor necrosis factor(TNF) and interleukin-l (IL-1 ) were determined on 1,3,5,7 and 10 PBDs and their correlations were analyzed. Results The postburn REE and plasma contents of TNF, LPS and IL-1 were much higher in both groups than those before injury. When compared between the two groups,the above data in D group were lower in varying degrees than those in B group. It was shown hy correlation analysis that REE was postively correlated to LPS, TNF and IL-1, respectively (γ= 0. 77 ~ 0. 9, P < 0. 05 ~ 0. 01 ). Conclusion Postburn hypermetabolism in rats could be ameliorated by gut decontamination,and the postburn plasma inflammatory mediators in rats could also be lowered by gut decontmination. This suggests that entero- genic hypermetabolism does exist after burn injury.
出处
《中华烧伤杂志》
CAS
CSCD
2001年第4期207-209,共3页
Chinese Journal of Burns
基金
全军"九五"指令性课题资助项目(96L043)
