摘要
本文应用流式细胞仪和单克隆抗体检测76例宫颈癌患者治疗前、后以及6个月后外周血T细胞亚群的分布。实验结果表明,患者外周血中总T细胞(OKT_3)低于正常对照组(p<0.05),T辅助/诱导细胞亚群(OKT_4)随肿瘤进展而下降,T抑制细胞亚群(OKT_8)明显上升,T_4/T_8值有显著差异(p<0.001)。各期宫颈癌治疗后显示总T细胞下降,T_4亚群变化不大,T_8亚群Ⅰ期下降,Ⅲ期上升明显。T_4/T_8值Ⅰ期正常,Ⅱ期略下降,Ⅲ期比例倒置。临床观察宫颈癌T细胞亚群的动态,能客观地反映宫颈癌患者的免疫状况,为临床提供一定的参数。
T lymphocyte subsets in peripheral blood of 76 cases with cervical cancer duringpretreatment, posttreatment and sixth month of posttreatment were investigated byusing monoclonal antibodies with flow cytometry. The results showed that the numberof T_8 cells (Pan T cell) were lower than the normal group(p<0.05); the number of T_4cells (Th/i cell) decreased and T_8 cells (Ts/c cell) increased as the tumor developed.The difference in T_4/T_8 ratio was significant(p<0.001)。After treatment the numberof total T cells reduced in all cases; no significant changes were found in T_4 cel-ls, and T_8 cells were reduced in stage Ⅰand increased significantly in stage Ⅲ. T_4/T_8 ratio was normal in stage Ⅰ, a few reduced in stage Ⅱ, and was upside down instage Ⅲ. This result may be used as a sensitive parameter to reflect host immunity.
出处
《肿瘤》
CAS
CSCD
北大核心
1993年第1期18-20,共3页
Tumor
