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HIF-1α与TRAIL-DR4在宫颈癌组织中的表达及与放疗敏感性的研究 被引量：5

Expressions of HIF-1αand TRAIL-DR4 in cervical cancer and their relationships with radiosensitivity
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摘要 目的:研究缺氧诱导因子-1α(HIF-1α)及肿瘤坏死因子相关的凋亡诱导配体(TRAIL)受体在宫颈癌组织中的表达变化,及与放疗敏感性的关系。方法:收集2003年7月至2005年1月宫颈癌活检组织45例,用原位杂交组织化学法检测宫颈癌组织中HIF-1αmRNA及TRAIL-DR4mRNA水平。结果:(1)在45例宫颈癌组织中27例(60%) HIF-1αmRNA呈阳性表达,Ⅰ/Ⅱ期肿瘤HIF-1αmRNA的表达显著低于Ⅲ/Ⅳ期肿瘤的表达(X^2=9．07,P＜0．05),随着组织分化的降低,HIF-1αmRNA的表达增强(X^2=8．03,P＜0．05),放疗敏感患者中HIF-1αmRNA表达明显低于放疗不敏感患者(X^2=10．37,P＜0．05);(2)TRAIL-DR4mRNA阳性表达率为57．8%。Ⅰ/Ⅱ期肿瘤DR4mRNA的表达显著高于Ⅲ/Ⅳ期肿瘤的表达(X^2=9．01,P＜0．05),中高分化宫颈癌的表达明显高于低分化宫颈癌(X^2=18．18,P＜0．05),放疗敏感患者中TRAIL-DR4mRNA表达明显高于放疗不敏感患者(X^2=6．91,PP＜0．05)。结论:HIF-1αmRNA及TRAIL-DR4mRNA与宫颈癌的放疗敏感有相关性。 Objective： To study the expressions of hypoxia-inducible factor -1α and TNF related apoptosis inducing ligand receptor in cervical cancer tissue and their relationships with radiosensitivity. Method：Forty-five samples from patients with cervical cancer were assessed for HIF-1 α and TRAIL-DR4 mRNA expression by in situ hybridization histochemistry （ISHH）. Rusult： （ 1 ） HIF-1α mRNA was over expressed in 27 samples （60%）. The level of expression in early stages（ Ⅰ and Ⅱ ）cases was lower than that in advanced stages （ Ⅲ and Ⅳ ） cases （ X^2 = 9.07, P 〈 0.05 ）. The expression of HIF-1α elevated as the pathologic grade decreased （ X^2 = 8.03, P 〈 0.05 ）. Patients who had complete response to radiotherapy were found to have lower HIF-1α tmRNA expression than those who were not sensitive to radiotherapy（ X^2 = 10.37,P 〈0.05）. （2）The positive rate of DR4mRNA was 57.8%. The level of expression in early stages（ Ⅰ andⅡ ）cases was higher than that in advanced stages（ Ⅲ and Ⅳ ）cases （X^2 = 9.01 ,P 〈0.05 ）. The positive rate of DR4 mRNA expression in well-differentiated cases was significantly higher than that in poorly differentiated cases. （X^2 = 18.18, P 〈 0.05 ）. Patients who showed complete response to radiotherapy were found to have higher DR4mRNA expression, than those who showed incomplete response to radiotherapy （ X^2 = 6.91, P 〈 0.05 ）. Conclusion：The expression of HIF-1α and TRAIL-DR4 are related to radiosensitivity.
作者 杨斌 瞿全新
机构地区 天津医科大学总医院妇产科
出处 《现代妇产科进展》 CSCD 北大核心 2007年第1期21-24,I0003,共5页 Progress in Obstetrics and Gynecology
关键词 宫颈肿瘤 缺氧诱导因子-1Α 肿瘤坏死因子相关诱导凋亡配体 放疗敏感性 Cervix neoplasms Hypoxia-inducible factor 1α TNF related apoptosis inducing ligand Radiosensitivity
分类号 R737.33 [医药卫生—肿瘤]
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参考文献8

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共引文献4

同被引文献52

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现代妇产科进展
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