摘要
目的 探讨慢性阻塞性肺病 (COPD)Ⅱ型呼吸衰竭患者及其子女的呼吸驱动反应性的变化 ,并对其遗传性进行初步探讨。方法 测定 6例COPDⅡ型呼吸衰竭患者及其 2 1名子女的口腔阻断压 (P0 .1) ,同时测定了P0 .1及分钟通气量 (VE)对低氧 (ΔP0 .1/ΔSaO2 和ΔVE/ΔSaO2 )和对高二氧化碳(ΔP0 .1/ΔPETCO2 和ΔVE/ΔPETCO2 )的反应性。结果 (1)COPDⅡ型呼吸衰竭患者的P0 .1显著高于其子女组和正常对照组 ,低氧呼吸中枢驱动反应性 (ΔP0 .1/ΔSaO2 )则显著低于子女组和正常对照组 (P <0 0 5 )。 (2 )受检患者的 10名子女低氧呼吸中枢驱动反应性低于正常对照组 ,而另 11名子女则正常 ,2组子女的性别分布均等。 (3)患者组高二氧化碳通气反应性 (ΔVE/ΔPETCO2 )显著低于正常对照组 ,子女ΔVE/ΔPETCO2 变异范围较大。结论 (1)低氧呼吸中枢驱动反应性降低可能是导致COPD患者发生二氧化碳潴留的原因。 (2 )低氧呼吸中枢驱动反应性降低可能受遗传因素的影响。
Objective To investigate the breath drive response of COPD patients and their offspring and to analyze the potential heredity. Methods P 0.1 and ventilatory response to hypoxia (ΔV E/ΔSaO 2),P 0.1 response to hypoxia (ΔP 0.1 /ΔSaO 2 ),P 0.1 response to hypercapnia (ΔP 0.1 /ΔP ET CO 2ΔV E/P ET CO 2) and ventilatory response to hypercapnia (ΔV E/P ET CO 2) were measured in 6 COPD patients with type Ⅱ respiratory failure and in 21 of their normal adult offspring. Results (1) P 0.1 was remarkably higher among all of the COPD patients than among their offspring and normal controls. The hypoxia response (ΔP 0.1 / ΔSaO 2) and ΔP 0.1 /ΔP ET CO 2 were significantly decreased among the COPD patients ( P <0.05).(2) The hypoxia response was low among 10 of the offspring of COPD patients, and was normal among the other 11. (3)The ventilatory response to hypercapnia (ΔV E/ΔP ET CO 2) was significantly decreased among the COPD patients, and varied greatly among their offspring. Conclusion (1) The depression of respiratory responses to hypoxia and hypercapnia may be the reason of type Ⅱ respiratory failure. (2) The depression of hypoxia response may be influenced by genetic factors.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2001年第6期348-351,共4页
National Medical Journal of China
基金
国家自然科学基金!资助项目 (39770 337)
