摘要
目的:探讨脾虚证结肠癌组织和正常结肠组织5-羟色胺受体1F(5-HTR1F)的表达差异并探讨其可能的临床意义。方法:中医辨证符合脾虚证的结肠癌患者32例为研究组,以18例同期湿热证结肠癌患者为对照组,SP免疫组化检测两组病例结肠癌组织和相邻结肠黏膜组织5-HTR1F的表达。结果:两组患者肿瘤组织中5-HTR1F的阳性表达率为74.4%,其相邻的结肠黏膜组织中5-HTR1F的阳性表达率为24.3%,两组表达有显著差异;脾虚证患者肿瘤组织中5-HTR1F的阳性表达率为87.5%,湿热证患者肿瘤组织中5-HTR1F的阳性表达率为55.6%,两组表达有显著差异,在不同TNM分期、有无淋巴结转移、肿瘤浸润深度有统计学意义。结论:5-HTR1F的表达可能与结肠癌发生发展相关,并可作为结肠癌脾虚证的预测指标。
Objective To explore the expression and role of Serotonin receptor （5-HTR1F） in the tissue of human colon cancer with deficiency in spleen qi. Methods The expression of 5-HTR1F was detected by SP immunohistochemistry. Results Among the 5- patients with colon cancer underwent radical resection, 32 pa-tients were with syndrome of deficiency of spleen qi,18 patients were with syndrome of dampness-heat. The ex-pression of 5-HTR1F was significantly different between patients with deficiency of spleen qi and patients with syndrome of dampness-heat.The difference had a statistical significance in the TNM pathological classification, lymph node metastasis and depth of invasion. Conclusion The expression of 5-HTR1F may be associated with the development of colon cancer and be used as the prediction index of human colon cancer for those with deficiency in spleen qi.
出处
《中国中西医结合外科杂志》
CAS
2014年第3期234-236,共3页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
基金
上海市卫生与计划生育委员会资助(2012L029A)
顾氏外科流派建设项目(ZYSNXD-CC-APGC-JD002)
关键词
结肠癌
脾虚证
临床病理
Colon cancer
deficiency of spleen qi
5-hydroxytryptamine receptor 1F
clinical pathology
