摘要
目的:探讨胃癌患者术前检测血清CA19-9的必要性及其对患者预后评估的意义。方法:收集2003年1月至2008年10月间天津医科大学肿瘤医院收治的513例术前检测血清CA19-9的胃癌患者的临床病理资料,分析CA19-9水平与临床病理因素的关系及其与预后的关系。结果:513例患者中CA19-9升高者86例(16.8%),CA19-9升高与高龄、大体分型(BorrmannⅢ、Ⅳ型)、组织学类型(低分化、未分化)及浸润深度相关。CA19-9正常(<39 U/mL)和升高(≥39 U/mL)患者5年生存率分别为45.7%和25.6%,差异有统计学意义(P<0.001)。分层分析显示,CA19-9水平仅与TNMⅢ期患者预后相关(P=0.001)。多因素预后分析证实,CA19-9升高是影响胃癌患者根治术后生存的独立危险因素(HR=1.47,P=0.008)。结论:术前检测血清CA19-9可为胃癌患者预后评估提供信息,CA19-9升高可能是胃癌根治术后影响患者预后的独立危险因素。
Objective：The influences of detection of the preoperative level of serum CA19-9 were analyzed on the prognosis of gastric cancer patients. Methods：A total of 513 gastric patients with preoperative CA19-9 detection were enrolled and underwent radical gastrectomy in Tianjin Medical University Cancer Institute and Hospital from January 2003 to October 2008. Clinico-pathological variables associated with the CA19-9 level were analyzed, and the prognostic value of CA19-9 was evaluated. Results：Eighty-six （16.8%） patients manifested an increased CA19-9 level, which was associated with ageing, Borrmann typesⅢandⅣ, undifferentiated type, and advanced T stage. The five-year survival rates were 45.7%and 25.6%for patients with normal （〈39 U/mL） and significantly high CA 19-9 levels （≥39 U/mL）, respectively. Differences in survival rates between the patient groups were statistically significant （P〈0.001）. Tumor-node-metastasis （TNM）-stratified analysis revealed a difference in overall survival for patients with stageⅢtumors. The significantly increased CA19-9 level was an independent prognostic factor for gastric cancer patients after radical surgery based on multivariate analysis. Conclusion：Detection of preoperative level of serum CA19-9 could provide important information for prognostic evaluation of gastric cancer patients. CA19-9 was a potential independent prognostic factor for gastric cancer patients after surgery.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2014年第11期702-706,共5页
Chinese Journal of Clinical Oncology
基金
国家重点研究发展973计划项目(编号:2010CB529301)资助~~
关键词
胃肿瘤
CA19-9
预后
stomach neoplasm, serum CA 19-9, prognosis
