摘要
采用饱和水溶液法制备2-巯基丙酸/β-环糊精包合物,利用紫外分光光度法测定包合物中2-巯基丙酸的含量,并通过正交实验对其包合工艺进行优化,结果表明:m(β-环糊精)∶m(2-巯基丙酸)=12∶1、包合温度为40℃、包合时间为5 h时,包合率达到74.95%。利用显微镜法、扫描电镜法、紫外分光光度法、红外光谱法对包合物的结构进行验证。
The β-cyclodextrin inclusion compound of 2-mercaptopropionic acid was prepared by saturated water solution method, and the content of 2-mercaptopropionic acid of inclusion compound was tested by ultraviolet spectrophotometry and the synthesis process was optimized by orthogonal experimental design. The results show that the optimized conditions were as follows ：m（β-cyclodextrin） ：m（2-mercaptopropionic acid） = 12：1 ;the inclusion temperature was 40℃ ;the inclusion time was 4 h. Under such optimum conditions,the inclusion rate can reach 74. 95%. Then the structure of the inclusion complex was characterized by means of digital liquid crystal biological microscope, scanning electron microscope, ultraviolet spectrophotometry and infrared spectroscopy.
出处
《精细化工》
EI
CAS
CSCD
北大核心
2014年第6期681-685,共5页
Fine Chemicals
基金
国家自然科学基金项目(81302706)~~
关键词
2-巯基丙酸
Β-环糊精
包合
正交实验
功能材料
2-mercaptopropionic acid
β-cyclodextrin
inclusion
orthogonal design
functional materials
