摘要
目的 建立客观、准确地评价创面愈合的标准。方法 对近年来国内外有关文献进行检索 ,总结。结果 筛选了创面愈合率、创面愈合时间、组织病理学分析、巨噬细胞定量分析、羟脯氨酸含量测定、细胞增殖情况、细胞 DNA含量和细胞周期分析、转化生长因子 - α水平、白细胞介素 - 1、白细胞介素 - 6和肿瘤坏死因子水平、角质细胞胶原酶 - 1含量测定、成纤维细胞生长因子受体 - 1水平、单核细胞化学诱导蛋白 - 1水平和角质细胞纤溶酶原活化抑制剂 - 2水平等十三种创面愈合评价指标。结论 创面愈合率、创面愈合时间及组织病理学分析仍是最直接而有效的创面愈合评价指标。
Objective To set up some objective and accurate criteria to evaluate wound healing. Methods Documents about wound healing were reviewed and summarized in detail. Results Wound healing rate, wound healing time, histopathology analysis, quantity assay of macrophage, determination of hydroxyproline. proliferation of cell, assay of DNA contents and circle of cells, level of transforming growth factor-α, levels of interleukin-1, interleukin-6 and tumor necrosis factor, assay of keratinocyte collagenase-1, level of fibroblast growth factor receptor-1, level of monocyte chemoattractant protein-1 and level of keratinocyte plasminogen activator inhabitor type 2 were selected as the evaluation criteria of wound healing. Conclusion Wound healing rate, wound healing time and histopathology analysis are direct and efficient criteria of wound healing.
出处
《中国修复重建外科杂志》
CAS
CSCD
2001年第2期126-128,F003,共4页
Chinese Journal of Reparative and Reconstructive Surgery
