摘要
目的:探讨了食管癌患者手术治疗前后血清TGF-α、TGF-β_1和VEGF水平的变化及临床意义。方法:应用放射免疫分析和酶联法对31例食管癌患者进行了血清TGF-α、TGF-β_1和VEGF测定,并与35名正常人作比较。结果:食管癌患者在术前TGF-α、TGF-β_1和VEGF水平非常显著地高于正常人组(P<0.01),术后3个月则与正常人组比较无显著性差异(P>0.05)。结论:检测食管癌患者血清TGF-α、TGF-β_1和VEGF水平的变化与肿瘤的发生、发展密切相关。
Objective To invastigate the clinical significance of changes on serum TGF-α,TGF-β1 and VEGF levels after opera- tion in patients with esophageal cancer. Methods Serum TGF-α,TGF-β1 （with RIA）and VEGF（with ELISA） contents were meas- ured in 31 patients with esophageal cancer both before and after operation as well as in 35 normal controls. Results Before operation, serum TGF-α, TGF-β1 and VEGF levels were significantly higher than those in controls （P 〈 0.01 ）, after operation for 3 months, the serum TGF-α,TGF-β1 and VEGF levels in the patients were slight difference from those in controls（P 〉 0.05 ）. Conclusion Serum TGF-α,TGF-β, and VEGF levels were closely related to the development of tumor in patients with esophageal cancer.
出处
《放射免疫学杂志》
CAS
2012年第2期142-143,共2页
Journal of Radioimmanology
关键词
食管癌转化生长因子-α
转化生长因子-Β1
血管内皮生长因子
esophageal cancer, transforming growth factor-a（TGF-α）, transforming growth factor-β1 （TGF-β1）, vascular en-dothelial growth factor（VEGF）
