摘要
急性心肌梗死是常见的心血管急症,是造成急性死亡的主要原因。心肌损伤标志物可以反映心肌坏死程度,为急性心肌梗死的诊断和预后判断提供重要信息。肌钙蛋白敏感性和特异性高,是目前临床中应用最广泛的心肌损伤标志物。然而肌钙蛋白起峰偏晚,不利于急性心肌梗死极早期的诊断。寻找敏感性准确性更高、起峰更快的新型心肌损伤标志物是冠心病领域研究的热点。最近的研究发现,急性心肌梗死时循环血中心肌特异性的微小RNA升高,可能作为心肌梗死新的生化指标,现对此做简要综述。
Acute myocardial infarction （AMI）, a common cardiovascular emergency, is the leading causes of acute death. Cardiac injury markers, which reflect the extent and severity of myocardial injury, provide crucial diagnostic and prognostic information for AMI patients. Cardiac troponin T and cardiac troponin I have been accepted as the most sensitive and specific cardiac injury markers and thus were widely used in the diagnosis of AMI. However, the rises of cardiac troponins were relatively slow and thus not useful in very early AMI. Searching for novel cardiac injury markers with higher diagnostic accuracy and rapid elevation after AMI was of great interest. Recent studies demonstrated that the circulating levels of some cardiac-specific miRNAs were significantly elevated after AMI and thus could be used as no vel cardiac injury markers. In this article, we summarized the recent clinical evidence of circulating microRNAs as a novel potential biomarker for early diagnosis of acute myocardial infarction.
出处
《心血管病学进展》
CAS
2014年第3期282-285,共4页
Advances in Cardiovascular Diseases
基金
四川省国际合作与交流项目(2012HH0032)
四川省科技支撑计划(2013SZ0082)
关键词
循环微小RNA
急性心肌梗死
肌钙蛋白
circulating microRNAs
acute myocardial infarction
cardiac troponin
