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循环微小RNA早期诊断心肌梗死研究进展 被引量：3

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摘要 微小RNA（microRNA，miRNA）是一类调控基因表达，高度保守的非编码miRNA（21～24nt），参与多种信号通路的调节，在维持内环境稳态中发挥重要作用[1]。从细胞分泌到外周血的miRNA称为循环miRNA，它们在正常人和各种疾病患者体内的表达谱存在明显的差异，并且稳定的存在于外周血中，从而具有诊断相关疾病的内在潜能[2]。作为miRNA家族的成员，近年来研究发现，miR-499、miR-208a、miR-208b最具心脏特异性，并且在急性心肌梗死（acutemyocardial infarction，AMI）早期的患者体内迅速升高，这就为AMI的早期诊治提供了新的思路和方法[3]。现就这一研究方向的进展做如下综述。
作者 苏彤 杨承健 李恒
机构地区 南京医科大学附属无锡市第二人民医院心内科
出处 《中华老年心脑血管病杂志》 CAS 北大核心 2013年第6期661-663,共3页 Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金 江苏省临床医学科技专项基金(BL2012042)
关键词 微RNAS 心肌梗死 早期诊断 肌钙蛋白 基因表达调控
分类号 R542.22 [医药卫生—心血管疾病]
  • 相关文献

参考文献27

  • 1Condorelli G, Latronico MV, Dorn GW 2nd. MicroRNAs in heart disease: putative novel therapeutic targets? Eur Heart J,2010,31=649-658.
  • 2Kosaka N, Iguchi H, Yoshioka Y, et al. Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem, 2010,285 .. 17442-17452.
  • 3Wang GK, Zhu JQ, Zhang JT, et al. Circulating micro RNA a novel potential biomarker for early diagnosis o{ acute myocar dial infarction in humans. Eur Heart J, 2010,31 : 659-666.
  • 4施冰,郭艳红,高炜.microRNA与心肌肥厚[J].中华老年心脑血管病杂志,2009,11(6):470-471. 被引量：2
  • 5Adachi T, Nakanishi M, Otsuka Y, et al. Plasma microRNA 499 as a biomarkcr of acute myocardial infarction. Clin Chem, 2010,56:1183 1185.
  • 6Ji X,Takahsshi R, Hiura Y,et al. Plasma miR 208 as a bio- marker of myocardial injury. Clin chem, 2009,55 : 1944 1949.
  • 7D'Alessandra Y,Devanna P, Limana F, et al. Circulating mi- croRNAs are new and sensitive biomarkers of myocardial in farction. Eur Heart J,2010,31:2765 2773.
  • 8Wang JX,Jiao JQ,Li Q,et al. miR 499 regulates mitochondri al dynamics by targeting calcineurin and dynamin related pro tein-1. Nat Med,2011,1771 78.
  • 9Bentwich I, Avniel A, Karov Y, et al. Identification of hundreds of conserved and nonconserved human microRNAs. Nat Genet,2005,37:766 770.
  • 10Sluijter JP, van Mil A,van Vliet P, et al. MicroRNA-1 and - 499 regulate differentiation and proliferation in human-derived cardiomyocyte progenitor cells. Arterioscler Thromb Vasc Bi- ol,2010,30:859 868.

二级参考文献33

  • 1Xie X,Lu J,Kulbokas EJ,et al.Systematic discovery of regulatory motifs in human promoters and 3 'UTRs by comparison of several mammals.Nature,2005,434,338-345.
  • 2van Rooij E,Sutherland LB,Liu N,et al.A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure.Proc Natl Acad Sci USA,2006,103:18255-18260.
  • 3Tatsuguchi M,Seok HY,Callis TE,et al,Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy.J Mol Cell Cardiol,2007,42,1137-1141.
  • 4Sayed D,Rane S,Lypowy J,et al.MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths.Mol Biol Cell,2008,19:3272-3282.
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  • 9Care A,Catalucci D,Felicetti F,et al.MicroRNA-133 controls cardiac hypertrophy.Nat Med,2007,13:613-618.
  • 10Duisters RF,Tijsen AJ,Schroen B,et al.MiR-133 and miR-30 regulate connective tissue growth factor:implications for a role of microRNAs in myocardial matrix remodeling.Circ Res,2009,104,170-178.

共引文献3

同被引文献21

  • 1O'gara PT, Kushner FG,AscheimDD,et al.2013 ACCF/AHA Guideline for the management of ST-elevation myocardial infarction:A report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines [J]. Circulation, 2013,127 (4) : e362.
  • 2Corsten MF, Dennert R, Jochems S, et al.Circulating microRNA-208b and microRNA-499 reflect myocardial damage in cardiovascular disease [J ]. Circ Cardiovasc Genet, 2010,3 (6) : 499.
  • 3Bostjancic E, Zidar N, Stajer D, et al. MicroRNAs miRl,rniR -133a,miR -133b and miR -208 are dysregulated in human myocardial infarction [ J ]. Cardiology, 2010, 115 (3) : 163.
  • 4Dimmeler S, Zeiher AM.Circulating mieroRNAs : novel biomarkers for cardiovascular disease [J]. Eur Heart J, 2010,31 (22) : 2705.
  • 5D' Alessandra Y, Devanna P, Limana F, et al. Circulating microRNas are new and sensitive biomarkers of myocardial infarction [J]. Eur Heart J,2010,31 (22) :2765.
  • 6Wang GK, Zhu JQ, Zhang JT, et al. Circulating micro- RNA:a novel potential biomarker for early diagnosis of acute myocardial infarction in humans[J].Eur Heart J,20/0,31(6) :659.
  • 7Recchioni R, Mareheselli F,Olivieri F, et al. Conventional and novel diagnostic biomarkers of acute myocardial infarction:a promising role for circulating microRNAs [ J ]. Biomarkers, 2013,18 (7) : 547.
  • 8Steg PG, James SK, Atar D, et al. ESC Guidelines for the management of acute myocardial infarction in patients with ST-segment elevation [J]. Eur Heart J, 2012, 33(20) :2569.
  • 9Kosaka N, Iguchi H, Yoshioka Y, et al. Secretory mechanisms and intercellular transfer of microRNAs in living cells I J]. J Biol Chem, 2010,285:17442.
  • 10Ai J,Zhang R, Li Y, et al. Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction [ J ].Biochem Biophs Res Commun, 2010,39 : 73.

引证文献3

二级引证文献39

中华老年心脑血管病杂志
2013年 第6期

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