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NADPH氧化酶与糖尿病肾病

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摘要 还原型烟酰胺腺嘌呤二核苷酸磷（NADPH）氧化酶是许多活性氧自由基（ROS）产生的主要来源,在高糖、高脂等作用下,NADPH氧化酶被激活,催化产生大量ROS,参与氧化应激,并作为氧化应激的核心酶,通过PKC调节、多元醇途径等一系列途径,影响肾脏血流动力学、肾小球滤过等,从而导致糖尿病肾病（DN）的发生.NADPH氧化酶抑制剂及抗氧化剂可以通过降低氧化应激水平,对肾脏起保护作用,为DN的临床防治提供新的研究方向和治疗靶点.
作者 蔡娜娜 刘宽芝
机构地区 石家庄河北医科大学第三医院内分泌一科
出处 《国际泌尿系统杂志》 2014年第3期445-448,共4页 International Journal of Urology and Nephrology
关键词 糖尿病肾病 NADPH氧化酶
分类号 R587.2 [医药卫生—内分泌] R692 [医药卫生—泌尿科学]
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参考文献22

  • 1Kleniewska P,Piechota A,Skibska B,et al.The NADPH oxidasefamily and its inhibitors[J] .Arch Immunol Ther Exp (Warsz),2012,60(4):277-294.
  • 2Syed I,Kyathanahalli C N,Jayaram B,et al.Increased phagocytelikeNADPH oxidase and ROS generation in type 2 diabetic ZDFrat and human islets:role of Rac1-JNK1 /2 signaling pathway inmitochondrial dysregulation in the diabetic islet[J] .Diabetes,2011,60(11):2843-2852.
  • 3Gill PS,Wilcox CS.NADPH oxidases in the kidney[J] .AntioxidRedox Signal,2006,8(9/10):1 597-1 607.
  • 4Gorin Y,Block K,Hemander J,et al.Nox4 NAD(P) H oxidase mediates hypenrophy and fibronectin expression in the diabetic kidney[J] .J Biol CIlem,2005,280:39616-39626.
  • 5BrownleeM.Biochemistry and molecular cell biology of diabetic com2p lications.Nature,2001; 414 (6865):813-820.
  • 6Hu C,Cong XD,Dai DZ,et al.Argirein alleviates diabetic nephropathy through attenuating NADPH oxidase,Cx43,and PERK in renal tissue[J] .Naunyn Schmiedebergs Arch Pharmacol,2011,383(3):309-319.
  • 7Zhang R,Harding P,Garvin JL,et al.Isoforms and functions of NAD (P) H oxidase at the macula densa[J] .Hypertension,2009,53(3):556-563.
  • 8Piwkowska A,Rogacka D,Jankowski M,et al.Metformin induces suppression of NAD(P) H oxidase activity in podocytes[J] .BiochemBiophys Res Commun,2010,393(2):268-273.
  • 9Schena FP,Gesualdo L.Pat hogenetic mechanisms of diabetic nephropat hy[J] .J Am Soc Nephrol,2005,16 (Suppl 1):S30-33.
  • 10Quagliaro L,Piconi L,Assaloni R,et al.Intermittent high glucoseenhances apop tosis related to oxidative stress in human umbilical veinendothelial cells:the role of p rotein kinase C and NAD (P) H-oxidaseactivation[J] .Diabetes,2003,52(11):2795-2804.

二级参考文献26

  • 1于冬青,邓华聪,刘金波.辛伐他汀对糖尿病大鼠肾脏氧化应激的抑制作用[J].中国病理生理杂志,2006,22(4):824-825. 被引量：12
  • 2Sharma S, Oliver-Fernandez A, Liu W, et al. The impact of diabetie retinopathy on health-related quality of life[J]. Curr Opin Ophthalrnol, 2005,16(3) : 155 - 159.
  • 3Brownlee M. The pathobiology of diabetic complications: a unifying mechanism[ J ]. Diabetes, 2005,54 (6) : 1615 - 1625.
  • 4Du Y, Miller CM, Kem TS. Hyperglycemia increases mitochondrial superoxide in retina and retinal cells[J]. Free Radic Biol Med, 2003,35(11):1491 - 1499.
  • 5Haskins K, Bradley B, Powers K, et al. Oxidative stress in type 1 diabetes[J]. Ann NY Acad Sci, 2003, 1005 (11):43- 54.
  • 6Kowluru RA. Effect of reinstitution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats[J]. Diabetes, 2003,52(3) :818 - 823.
  • 7Robison WG, Kador PF, Kinoshita JH. Early retinal microangiopathy: prevention with aldose reductase inhibitors [J]. Diabetic Medicine, 1985,2(3) : 196 - 199.
  • 8Harhaj NS, Antonetti DA. Regulation of fight junctions and loss of barrier function in pathophysiology[J]. Int J Biochem Cell Biol, 2004,36(7) : 1206 - 1237.
  • 9Kowaltowski AJ, Castilho RF, Vercesi AE. Mitochondrial permeability transition and oxidative stress[J]. FEBS Lett, 2001,495(1/2) : 12 - 15.
  • 10Nishikawa T, Edelstein D, Du XL, et al. Normalizing mitochondrial superoxide production blocks three pathways of pathways of hyperglycaemic damage [ J]. Nature, 2000, 404(6779) :787 - 790.

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国际泌尿系统杂志
2014年 第3期

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