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球型脂联素对高糖诱导胰岛β细胞株NIT-1活性氧簇产生的影响 被引量：1

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摘要 β细胞功能障碍是2型糖尿病发病机制的一个重要环节；但长期高血糖如何损害β细胞功能的分子机制仍未完全清楚。研究表明氧化应激参与β细胞的“葡萄糖毒性”。球型脂联素（globular adiponectin，gad）与机体氧化应激水平有关，可能是通过还原型烟酰胺腺嘌呤二核苷酸磷酸[NAD（P）H]氧化酶相关机制，而NAD（P）H氧化酶途径是B细胞中活性氧簇（ROS）产生增加的重要途径之一。本实验探讨gAd对高糖诱导胰岛β细胞株NIT-1ROS的产生是否有影响，及其可能的相关机制。
作者 周嘉 李焱 杨川 徐明彤 李芳萍 严励 程桦 傅祖植
机构地区 中山大学附属第二医院内分泌科
出处 《中华内科杂志》 CAS CSCD 北大核心 2008年第2期147-148,共2页 Chinese Journal of Internal Medicine
基金 国家教委博士点科研基金（D002000001） 卫生部科学研究基金（0000099009）
关键词 胰岛Β细胞株 活性氧簇 高糖诱导 脂联素 NIT-1 NAD(P)H氧化酶 还原型烟酰胺腺嘌呤二核苷酸 球型
分类号 R686 [医药卫生—骨科学]
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参考文献10

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同被引文献8

  • 1Jonas JC,Sharma A,Hasenkamp W,et al.Chronic hyperglycemia triggers loss of pancreatic β--cell differentiation in an animal model of diabetes.J Biol Chem,1999,274:14112-14121.
  • 2Rabertson RP,Harmon J,Tran PO,et al.Glucose toxicity in β-cells:type 2 diabetes,good radicals gone bad,and the glutathione connection.Diabetes,2003,52:581-587.
  • 3Tao L,Gao E,Jiac X,et al.Adipenectin cardioprotection after yocardial ischemia/reperfasion involves the reduction of oxidative/nitrative stress.Circulation,2007,115:1408-1416.
  • 4Ouedraogo R,Wu XD,Xu SQ,et al.Adiponectin suppression of highglucose-induced reactive oxygen species in vasclar endothelial cells:evidence for involvement of a cAMP signaling pathway.Diabetes,2006,55:1840-1846.
  • 5Weir GC,Laybutt DR,Kanto H,et al.β-cell adaptation and decompensation during the progression of diabetes.Diabeles,2001,50:S154-S159.
  • 6Harmon JS,Stein R,Rabertson PR.Oxidative stress-mediated,posttranslational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells.J Biol Chem,2005,280:11107-11113.
  • 7Privratsky JR,Wold LE,Sowers JR,et al.AT1 blockade prevents glucose-induced cardiac dysfunction in ventricular myocytes:role of the AT1 receptor and NADPH oxidase.Hypertension,2003,42:206-212.
  • 8Ohashi K,Iwatani H,Kihara S,et al.Exacerbation of aldbuminuria and renal fibrosis in subtotal renal ablation model of adiponectin-knockont mice.Arterioscler Thromb Vase Biol,2007,27:1910-1917.

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中华内科杂志
2008年 第2期

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