摘要
目的筛选绞股蓝总皂苷固体自微乳化颗粒(GPS-SSEG)的最佳处方配比。方法以乳化时间、粒径等为指标制定评分标准,筛选GPS自微乳释药系统最佳处方;对不同固体吸附剂吸附自微乳化药液的能力和颗粒的成型率、粒径、溶出度进行考察,筛选固体自微乳化颗粒最优处方。结果优化的GPSSSEG处方为:吐温-80∶transcutol P∶油酸乙酯∶可溶性淀粉∶乳糖∶甘露醇的质量比为11∶6∶3∶60∶10∶10,分散后平均粒径为36 nm,在45 min的体外溶出度是原料药的5倍。结论 GPS-SSEG显著提高了绞股蓝总皂苷的体外溶出度。
Objective To prepare Gynostemma pentaphyllum total saponins solid self-emulsifying granules （ GPS-SSEG）. Methods The optimized L-SEDDS was optimized by studying index of emulsifying time and emulsifying diameter. GPS-SSEG was optimized by different solid sorbent, the different solid particles of the adsorbent in molding rate, particle size and in vitro dissolution. Results The composition of the optimized formulation was as follows： tween-80 ：transcutol P ：oleic acid ethyl ester：soluble starch ：lactose ：mannitol = 11：6：3：60：10：10. The particle diameter was 36 nm. The percent of accumulated dissolution of GPS in S- SMEDDS in vitro was five times of crude material at 45 rain. Conclusion The dissolution of GPS-SSEG was improved by SSEG.
出处
《广东药学院学报》
CAS
2014年第1期6-10,共5页
Academic Journal of Guangdong College of Pharmacy
基金
广东药学院重点培养教师资助计划
关键词
绞股蓝总皂苷
固体自微乳化颗粒
溶出度
Gynostemma pentaphyllum total saponins
solid self-emulsifying
dissolution
