摘要
细胞凋亡通路受阻是导致肿瘤发生、发展及产生耐药性的主要原因,通过死亡受体信号转导途径和线粒体途径诱导细胞凋亡,是近年来发现的抗肿瘤治疗的主要机制。壮药"国虾薄"通三道两路,具有清热解毒的作用其热处理产物具有很强的抑制非小细胞肺癌(NSCLC)A549细胞增殖活性,并诱导细胞凋亡。但其有效成分尚不明确,作用机制尚不清楚。本文介绍了细胞凋亡通路、壮医药抗肿瘤基本理论、热处理方法在天然药物中的应用、壮药"国虾薄"(绞股蓝)的生物活性及其热处理产物抗NSCLC有效成分研究。
@@@@Blocking the apoptotic pathway is the principal cause of the occurrence, development and drug resistance of tumor. Recently it was found that apoptosis induced via death receptor signal transduction path-ways and mitochondrial pathways was the main mechanism of anti-tumor treatment. “Gocaekmbaw”, the Zhuang-medicine, which possessedthe effects of keeping the “three channels and two ways” unblocked, and had the heat clearing and detoxication activities. The ethanol extract of the heat-processed Gocaekmbaw by high temperature and pressure conditions showed a stronger non-small cell lung carcinoma (NSCLC) A549 cells inhibitory activity and possessed an apoptosis induction effect. However, the active constituents of Go-caekmbaw and their mechanism were not clear yet. The apoptotic pathway, basic anti-tumor theory of Zhuang-medicine, application of heat-processing in natural medicine, biological activity of Gocaekmbaw, and research on active constituents against NSCLC from its heat-processed product were reviewed in this paper.
出处
《食品安全质量检测学报》
CAS
2013年第2期333-338,共6页
Journal of Food Safety and Quality
基金
国家自然科学基金项目(30973960
81011140347
81181240306
81274186)~~
关键词
非小细胞肺癌
国虾薄(绞股蓝)
细胞凋亡
壮医
non-small cell lung carcinoma
Gocaekmbaw(Gynostemma pentaphyllum)
apoptosis
Zhuang-medicine
