摘要
目的通过对支气管哮喘患者治疗前后TSLP及炎性因子的变化情况的对比研究,分析探讨支气管哮喘的作用机制。方法使用抗炎药物布地奈德对于支气管哮喘患者进行治疗,试验前后对患者TSLP的表达活性、含量及血浆中IL-4,IL-5,IL-13的含量,以及外周血单个核细胞(PBMCs)中CD40、CD80、CD86的表达水平进行检测,采用健康人数据作为对照组,并对检测结果进行统计对比,研究其变化及其之间关系。结果患者经治疗哮喘症状明显减轻,TSLP表达活性以及炎性因子的表达水平都显著减少,与对照组相比更为接近。结论布地奈德等抗炎药物可有效治疗支气管哮喘,降低TSLP等的表达水平,而该类指标与支气管哮喘的加重密切相关。
Objective To compare the study of changes in TSLP and inflammatory factors in patients with bronchial asth- ma before and after treatment, and to explore the mechanism of bronchial asthma. Methods Using anti - inflammatory drugs budesonide for the treatment of bronchial asthma, before and after test the patients＂ TSLP expression activity, the content and plasma IL-4, IL-5, IL- 13 levels, and peripheral blood mononuclear cells （PBMCs） of CD40, CD80, CD86 expression levels were detected using the data as a control group of healthy people, and the test results for statisti- cal comparison and study the relationship between the changes. Results The patients with asthma symptoms were re- lieved, TSLP expression levels of activity and expression of inflammatory factors were significantly reduced compared with the control group closer. Conclusion Budesonide is effective in treating anti - inflammatory drugs such as bronchi- al asthma, decreased expression levels of TSLP, whereas such a measure is closely related to the increase of bronchial asthma.
出处
《医药论坛杂志》
2014年第4期12-13,16,共3页
Journal of Medical Forum
