摘要
目的分析乙酰半胱氨酸联合氨溴索治疗老年慢性阻塞性肺疾病急性发作期的临床效果。方法选择本院2016年2月至2017年3月收治的104例老年慢性阻塞性肺疾病急性发作期患者作为观察对象,并按照随机抽签法将所有患者分为对照组和观察组,各52例。对照组患者给予盐酸氨溴索注射液治疗,而观察组则在对照组的基础上联合乙酰半胱氨酸片治疗。比较两组患者的临床疗效、治疗前后动脉血气指标、肺功能指标及不良反应发生率。结果观察组患者的治疗总有效率(90.38%)显著高于对照组(75.00%);治疗后,两组患者的血氧分压(PaO2)及FEV1/用力肺活量(FEV1/FVC)水平均比治疗前升高,动脉血二氧化碳分压(PaCO2)水平均比治疗前降低,但观察组的各项指标改善程度比对照组更明显(P<0.05);观察组不良反应发生率为(11.54%),对照组发生率为(15.38%),两组比较(P>0.05)。结论乙酰半胱氨酸联合氨溴索治疗老年慢性阻塞性肺疾病急性发作期的效果比单一用药更突出,可有效改善患者动脉血气及肺功能指标,更有利于患者机体康复,可作为临床首选治疗方案。
Objective To analyze the clinical effect of acetylcysteine combined with ambroxol in the treatment of acute onset of chronic obstructive pulmonary disease in the elderly.Methods 104 elderly patients with acute episodes of copd admitted to our hospital from February 2016 to March 2017 were selected as the observation objects,and all the patients were divided into control group and observation group by random lottery,with 52 cases in each group.The control group was treated with ambroxol hydrochloride injection,while the observation group was treated with acetylcysteine tablets on the basis of the control group.The clinical efficacy,arterial blood gas index,pulmonary function index and incidence of adverse reactions before and after treatment were compared between the two groups.Results The total effective rate(90.38%)in the observation group was significantly higher than that in the control group(75.00%).After treatment,the blood oxygen partial pressure(PaO2)and FEV1/forced vital capacity(FEV1/FVC)levels in both groups were higher than before treatment,and the arterial partial carbon dioxide pressure(PaCO2)levels were lower than before treatment,but the improvement degree of each index in the observation group was more obvious than that in the control group(P<0.05).The incidence of adverse reactions was 11.54%in the observation group and 15.38%in the control group(P>0.05).Conclusion The effect of acetylcysteine combined with ambroxol in the treatment of elderly patients with acute attack of chronic obstructive pulmonary disease is more prominent than that of single drug,which can effectively improve the indicators of arterial blood gas and lung function,and is more conducive to the recovery of patients,and can be used as the first choice of clinical treatment.
作者
朱志刚
ZHU Zhi-gang(Xianning Xian'an District Maternal and Child Health Hospital,Xianning 437000,China)
出处
《中国医药指南》
2020年第13期71-72,共2页
Guide of China Medicine
