摘要
目的探讨肿瘤坏死因子-α(TNF-α)基因308A多态性与缺血性脑卒中发病的相关性。方法电子检索2012年12月之前的中国生物医学文摘数据库、中国学术文献学库、万方数据库、维普网及PubMed等,收集有关TNF-α基因308A多态性与缺血性脑卒中的病例-对照研究。评价纳入研究质量,提取有效数据,采用Stata 12.0软件进行Meta分析。通过将多个同类研究进行综合,进一步阐明二者的关联。结果共纳入12个研究TNF-α-308A基因多态性与缺血性脑卒中关系的病例对照研究。以GG型基因为参照,携带GA+AA基因型个体发生缺血性脑卒中风险无明显增高[OR=0.98,95%CI(0.84,1.16),P=0.548]。结论 TNF-α-308A基因多态性可能与缺血性脑卒中发病不相关。
Objective To investigate the association of the polymorphism of the tumor necrosis factor-α（TNF-α） and cerebral arterial thrombosis. Methods We electronically searched CBM, CNKI, Wanfang database,VIP and PubMed before 2012. 12 to collect case studies on TNF-α-308A polymorphism and cerebral arterial thrombosis. We evaluated the quality of the included studies and the extracted data. Stata 12. 0 was used for meta-analyses. Results We identified 12 case-control studies on association of TNF polymorphism and cerebral arterial thrombosis. People with GA ＋ AA genotypes of TNF-α had no higher risk of cerebral arterial thrombosis [ OR = 0.98,95 % CI （0. 84,1.16） , P = 0. 548 ]. Conclusion Our findings suggest that TNF-α polymorphisms might be not associated with cerebral arterial thrombosis.
出处
《中华脑科疾病与康复杂志（电子版）》
2014年第1期36-39,共4页
Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）
基金
上海市卫生局科研基金(2012-460)
上海市高级中西医结合人才培养项目(ZYSND012-RC-ZXY019)
关键词
肿瘤坏死因子Α
卒中
多态性
单核苷酸
META分析
Tumor necrosis factor-alpha
Stroke
Polymorphism, single nucleotide
Meta-analysis
