摘要
目的探讨宫颈环形电切术(LEEP)和宫颈冷刀锥切术(CKC)治疗高级别宫颈上皮内瘤变(CINII、Ⅲ)的优势。方法选取我院300例高级别CIN患者,按照手术方式分为LEEP组和CKC组,每组150例,观察比较两组手术时间、术中出血量和复发情况。结果 LEEP组手术时间和术中出血量分别为(7.0±5.1)min和(8.1±4.5)ml,均明显低于CKC组的(36.5±9.7)min和(46.9±12.9)ml,差异均有统计学意义(t=32.968,34.782,P<0.0,1)。所有患者术后随访2年,LEEP组3月内病灶残留6.7%,术后6月、12月、24月复发率分别为8.7%、11.3%和13.3%,均明显高于CKC组(0.7%、1.3%、2.7%和3.3%),差异均有统计学意义(χ2=7.644,8.491,8.653和9.818,P<0.0,1)。结论 LEEP组相对CKC组手术时间短、术中出血少,适合基层医院,但CKC组复发率低,两种方法各有优势。
Objective To investigate the advantages of cervical loop electrosurgical excision procedure （LEEP） and cervical cold knife conization （CKC） in the treatment of high-grade cervical intraepithelial neoplasia （CINII, IU ）. Methods 300 patients with high-grade CIN hospitalized in our hospital were divided into LEEP group and CKC group according to surgical methods, 150 cases in each group. Operative time, blood loss and recurrence of the two groups were compared. Results Average operative time and blood loss in the LEEP group （7.0± 5. 1 min, 8.1 ＋ 4.5ml） were significantly less than those in the CKC group （36.5 ±9.7rain, 46.9±12.9ml）, the differences between the two groups were statistically significant （ t = 32. 968,34. 782, P 〈 0. 01 ）. All patients were followed up for two years, residual lesions in the LEEP group was 6.7%. Recurrence rates ware 8.7 %, 11.3 % and 13.3 % at time points 6 months, 12 months, 24 monthsafter followed up, significantly higher than that in the CKC group （0.7 %, I. 3 %, 2.7% and 3.3 % ） （ X5 = 7. 644,8.491,8. 653and 9.818, P 〈 0. O, 1 ）. Conclusions Both of the surgical methods have advantages, but different from each other. LEEP has the advantages such as less operative time and bleeding, and CKC with low recurrence rate.
出处
《齐齐哈尔医学院学报》
2014年第6期792-793,共2页
Journal of Qiqihar Medical University
关键词
宫颈上皮内瘤变
宫颈癌
宫颈环形电切术
宫颈冷刀锥切术
复发率
Cervical intraepithelial neoplasia
Cervical cancer
Cervical loop eleetrosurgical excision procedure
Cervical cold knife conization
relapse rate
