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自体外周血造血干细胞移植支持下大剂量化疗一线治疗外周T细胞淋巴瘤 被引量：4

Therapeutic efficacy of peripheral T cell lymphoma patients treated with first-line intensive chemotherapy followed by autolo-gous stem cell transplantation
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摘要 目的探讨自体外周血造血干细胞移植（ASCT）支持下大剂量化疗在外周T细胞淋巴瘤一线治疗中的疗效。方法总结2000年1月至2011年1月间进行的自体外周造血干细胞移植支持下的大剂量化疗的23例外周T细胞淋巴瘤患者的临床资料，并与同期进行的23例常规治疗的患者作非随机比较，所有患者均予以E—CHOP方案化疗6～8周期，移植组达完全缓解或部分缓解后行ASCT支持下大剂量化疗。结果移植组近期疗效与常规化疗组比较差异无统计学意义（P〉0．05），移植组5年总生存率（0s）（58％）高于常规化疗组（32％），移植组5年无病生存率（DFS）（45％）亦高于常规化疗组（2l％），差异皆有统计学意义（P〈0．05）。两组严重毒副反应比较中，仅移植组Ⅳ度骨髓抑制发生率（100％）高于常规化疗组（13％），差异有统计学意义（P〈0．01）。结论ASCT支持下大剂量化疗治疗外周T细胞淋巴瘤安全有效，其疗效优于常规化疗，可作为PTCL一线治疗。 Objective To investigate the outcomes of unselected peripheral T cell lymphoma （PTCL） patients treated with in- tensive first-line chemotherapy with high-dose therapy followed by autologous stem cell transplantation （ASCT）. Methods Here a nonrandom study was reported for 23 PTCL patients treated with first-line intensive chemotherapy followed by autologous stem cell trans- plantation and 23 PTCL patients treated with conventional chemotherapy during January in 2000 to 2011. All patients had received E- CHOP for 6 - 8 cycles, and autologous stem cell transplantation group was administrated with intensive chemotherapy followed by ASCT after complete remission or partial remission. Results There was no statistically significant difference in short-term therapeutic effect between two groups（ P 〉0. 05）, but the 5-year overall survival（OS） of autologous stem cell transplantation group （58%） was higher than conventional chemotherapy group, as well as 5-year disease-free survival time （DFS） （45% in autologous stem cell transplanta- tion group, and 21% in conventional chemotherapy group） with both statistical significance （ P 〈0. 05）. Only the incidence of IV~ myelosuppression in autologous stem cell transplantation group （100%） was higher than that in conventional chemotherapy group （ 13 % ） （ P 〈 0. 01 ）. Conclusions First-line intensive chemotherapy followed by autologous stem cell transplantation for peripheral T cell lymphoma was quietly safe utility, it was better than conventional chemotherapy which would be considered as first-line method.
作者 姚远 易平勇 刘晰宇 周芳 孙中义 欧阳周 贺军侨 黄利军
机构地区 湖南省肿瘤医院中南大学湘雅医学院附属肿瘤医院淋巴瘤血液内科
出处 《中国医师杂志》 CAS 2014年第2期227-230,共4页 Journal of Chinese Physician
关键词 移植 自体 外周血干细胞移植 淋巴瘤 T细胞 外周 外科学 淋巴瘤 T细胞 外周 药物疗法 综合疗法 Transplantation, autologous Peripheral blood stem cell transplantation Lymphoma, T-cell, peripheral/surgery Lymphoma, T-cell, peripheral/drug therapy Combined modality therapy
分类号 R733.1 [医药卫生—肿瘤]
  • 相关文献

参考文献10

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共引文献17

同被引文献40

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中国医师杂志
2014年 第2期

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