摘要
目的 :观察经皮穿刺冠状动脉腔内成形术 (PTCA )对冠脉循环肿瘤坏死因子α(TNF-α)水平的影响。 方法 :采用生物活性法检测 PTCA前后冠状窦 (CS)及股动脉 (AO)血浆 TNF-α水平。 结果 :与 PTCA前相比 ,术后即刻 AO血浆 TNF-α水平升高 [(15 .86± 3.75 ) U / ml对 (4 1.32± 4.36 ) U / ml,P<0 .0 1],而术后即刻 CS血浆 TNF-α水平升高更为显著 [(16 .72± 4.14) U/ ml对 (96 5 .6 1± 6 .2 5 ) U / ml,P<0 .0 1]。术后 2 4h AO血浆 TNF-α[(18.32± 5 .12 ) U / ml]与术前比较无显著差异(P>0 .0 5 )。结论 :术后血浆 TNF-α活性增高可能与 PTCA时冠状动脉内膜损伤有关 ,TNF-α是否参与了
Objective:To observe the effect of percutaneous transluminal coronary angioplasty (PTCA) on coronary circulating tumor necrosis factor α (TNF α) activity. Methods: Plasma TNF α levls were measured with radioimmunoassay and bioactive assay respectively. Results: Plasma TNF α activity in femoral artery (AO) was significantly increased immediately after PTCA [(15.86±3.75) U/ml vs (41.32±4.36) U/ml, P <0.01], and plasma TNF α activity in coronary sinus was remarkably increased immediately after PTCA [(16.72±4.14) U/ml vs (65.61±6.25) U/ml, P <0.01]. There was no change in plasma TNF α activity in AO 24 h after PTCA [(18.32±5.12) U/ml vs (15.86±3.75) U/ml, P >0.05]. Conclusion: The increase in plasma TNF α activity after PTCA may be associated with the injury of coronary artery caused by PTCA, suggesting that TNF α may be involved in the coronary occlusion and the development of coronary restenosis after PTCA. [
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2001年第2期185-186,共2页
Academic Journal of Second Military Medical University
基金
国家自然科学基金资助项目 !(3 9670 3 16)
关键词
肿瘤坏死因子
再狭窄
冠心病
PTCA冠脉循环
angioplasty,transluminal,percutaneous coronary
percutaneous transluminal coronary angioplasty
tumor necrosis factor
restenosis
coronary circulation
arterial occlusive disease
