摘要
在胰腺癌的生长和转移中新生血管形成(Angiogenesis)是其从小结节进展成为具有侵袭能力重要的一步。血管内皮生长因子是肿瘤血管新生过程中最重要的驱动因子,血管新生的主要调节者。随着VEGF途径作用机制研究的日益深入,VEGF与胰腺癌的关系也受到越来越多的关注。本文从VEGF的结构和功能、调控因素及相关调控机制,VEGF在胰腺癌中表达的临床意义,以及抗VEGF治疗在胰腺癌中的相关研究进展方面,对VEGF在胰腺癌中的研究现状做一介绍。
In the growth and metastasis process of pancreatic carcinoma, anglogenesls Is a vital step wmcn mares the tumor have the ability of metastasis from a small nodule. Vascular endothelial growth factor （VEGF） is viewed as a cru- cial driving factor and the major regulator in the process of angiogenesis. With the deepening research of the mechanism of VEGF pathway, studies on VEGF and pancreatic cancer have become a focusing topic. Therefore, the relationship between VEGF and pancreatic carcinoma is reviewed in this article. Then, we summarized the recent findings from the following as- pects： the characteristics of VEGF （including the structure and function, modulating factors and regulation mechanism）, the clinical significance of VEGF and anti-VEGF therapy in pancreatic carcinoma.
出处
《海南医学》
CAS
2014年第8期1157-1160,共4页
Hainan Medical Journal
关键词
血管内皮生长因子
胰腺癌
抗VEGF治疗
Vascular endothelial growth factor （VEGF）
Pancreatic carcinoma
Anti-VEGF therapy
