摘要
目的:探讨前列地尔致过敏性休克的规律和特点,为临床合理用药提供参考。方法:检索1979年1月-2013年7月相关数据库收载的中文医药卫生期刊中涉及前列地尔致过敏性休克的文献资料,并对13例不良反应的相关情况进行统计和分析。结果:发生过敏性休克的13例患者均为静脉途径给药;5例发生在用药10 min以内;以心血管系统和呼吸系统损害较多见;2例患者死亡,11例患者经治疗后恢复正常。结论:前列地尔致过敏性休克的相关因素很多,包括患者的体质因素、医者因素、药物制剂因素等,临床应加强对此种严重不良反应的监测。
OBJECTIVE： To explore the regularity and characteristics of anaphylactic shock induced by alprostadil, and to pro-vide reference for rational drug use in the clinic. METHODS： Literatures about anaphylactic shock induced by alprostadil published on Chinese medical journals during Jan. 1979-Jul. 2013 were retrieved from relevant database, and 13 cases of ADR were ana-lyzed statistically. RESULTS： 13 cases of anaphylactic shock were all induced by intravenous route of administration; 5 cases oc-curred within 10 min; most of clinical manifestations were cardiovascular system and respiratory system injury. There were 2 death cases, and 11 cases returned to normal after treatment. CONCLUSIONS ： There are many correlated factors of anaphylactic shock induced by alprostadil, including physical factor, physician and patient factor, pharmaceutical preparation factor, etc. Great impor-tance should be attached to severe ADR monitoring.
出处
《中国药房》
CAS
CSCD
2014年第16期1499-1501,共3页
China Pharmacy
关键词
前列地尔
过敏性休克
文献分析
Alprostadil
Anaphylactic shock
Literature analysis
