摘要
目的:了解真实世界中使用丹参川芎嗪注射液出现疑似过敏反应的影响因素。方法:回顾分析2006~2015年全国24家三级甲等医院信息系统(hospital information system,HIS)中使用丹参川芎嗪注射液患者的住院信息。采用巢氏病例对照的研究设计方法,以性别相同、年龄±3岁作为配比条件,按照1∶4的方法进行匹配。按照过敏反应的评价标准,将数据库中使用丹参川芎嗪注射液疑似过敏反应者为过敏组,未发生过敏反应者为对照组。采用Logistic回归分析方法,探讨合并用药、合并疾病、住院天数、疗程、单次剂量、日剂量等因素与使用丹参川芎嗪注射液后出现疑似过敏反应的相关性。结果:基于现有数据,前列地尔注射液、呋塞米片、恶性肿瘤可能与使用丹参川芎嗪注射液发生疑似过敏反应存在相关性。结论:研究提示临床使用丹参川芎嗪注射液合并恶性肿瘤以及联合应用前列地尔注射液、呋塞米片时发生过敏反应的可能性较大,应注意与规避发生过敏反应的风险。
Objective:To understand the suspicious allergic factors of Salviae Miltiorrhizae and Ligustrazine Hydrochloride injection in real world.Methods:The hospital information of patients with Salviae Miltiorrhizae and Ligustrazine Hydrochloride injection was retrospectively analyzed,using design methods retrospective nested case-control.The allergies group and control group were distinguished by the criteria for anaphylaxis evaluation.The logistic regression analysis is used to explore the correlation of allergic reactions.Result:Furosemide Tablets,Qiandil injection and malignant tumor may be related to the suspected allergic reaction of Salviae Miltiorrhizae and Ligustrazine Hydrochloride injection.Conclusion:The study suggested that the Salviae Miltiorrhizae and Ligustrazine Hydrochloride injection combined with Furosemide Tablets,Qiandil injection and malignant tumors were more likely to produce allergic reactions.It should pay attention to avoiding the risk of allergic reactions.
作者
李敏
谢雁鸣
章轶立
高阳
徐鸿燕
LI Min;XIE Yan-ming;ZHANG Yi-li;GAO Yang;XU Hong-yan(Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Scients,Beijing 100700,China;Eye Hospital,China Academy of Chinese Medical Science,Beijing 100040,China;Renmin University of China,School of Statistics,Beijing 100872,China)
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2019年第12期1707-1709,共3页
JOURNAL OF BASIC CHINESE MEDICINE
基金
中央级公益性科研院所基本业务费项目(Z0439)
中国中医科学院科技创新团队(PY1303)
中国中医科学院研究生教育教学改革研究项目资金资助(JG201703)。
关键词
丹参川芎嗪注射液
过敏反应
真实世界
巢氏病例对照研究
Salviae Miltiorrhizae and Ligustrazine Hydrochloride injection
Allergic reactions
Real world
Nested case control study
