摘要
目的:探讨宫颈鳞状上皮内瘤变(CIN)治疗后影响高危型人乳头瘤病毒(HR-HPV)清清除的相关因素。方法:对2008年10月至2009年12月在新疆自治区人民医院经阴道镜下活检诊断为CIN并采用第二代杂交捕获技术(HC2)检测HR-HPV阳性的90例患者进行宫颈锥切术,术后6月采用HC2技术行宫颈HR-HPV检测,对CIN治疗后影响HR-HPV清除的相关因素进行回顾性分析。结果:CIN治疗后切缘阳性组与切缘阴性组,治疗前高危型HPV病毒载量≥500RLU/PC组与<500RLU/PC组术后HR-HPV持续阳性率有差异。结论:切缘阳性及术前HR-HPV病毒载量≥500RLU/PC者宫颈锥切术后HR-HPV难以消除,应严密随访。
Objective： To approach the influential factors essociated with HPV persistence after conization. Methods： A retrospective study was conducted on 90 women who underwent LEEP or CKC for cervical intraepithelial neoplasm from august 2008 to December 2009.For all patient with HR-HPV positive hybrid capture II met＇hod was used to detect viral load of HR-HPV 6 months after treatment. Results： There WaS significant difference in persistent masculine of HR-HPV between positive margin group and negative margin group- （P=0.009）, HR-HPV viral load 500RLU/PC group and viral load 〈500RLU/PC group （P=0.013）. Conclusion： Persistent HPV infection after coniza tion was more likely to occur when the pretreatment vlralyload was ≥500 RLU/PC and the margin was posture.There- fore, patients With HR-HPV viral load ≥ 500RLU/PC and positive margin afier conization need to be followed closely.
出处
《新疆医学》
2013年第12期15-19,共5页
Xinjiang Medical Journal
基金
新疆维吾尔自治区自然科学基金资助项目(NO.2010211A55)
