摘要
目的:探讨重组人干扰素α-2b阴道泡腾胶囊(辛复宁)清除人乳头状瘤病毒(human papilloma virus,HPV)感染的临床疗效及机制。方法:将感染HPV患者分成实验组(辛复宁组)和对照组(淑润栓组,重组人干扰素α-2b栓剂),观察比较两组作用于阴道后穹隆后对HPV转阴率,ELASA检测两组作用前后局部细胞因子白介素-4(inter-leukin-4,IL-4、IL-10、干扰素γ(interferonγ,IFN-γ)、肿瘤坏死因子α(tumor necrosis factorα,TNF-α)的含量。结果:实验组HPV的转阴率高于对照组(P<0.05),且实验组IL-4、IL-10含量降低和IFN-γ、TNF-α含量升高更明显(P均<0.05)。结论:干扰素可以通过调节Th1/Th2平衡加强免疫清除病毒作用,且辛复宁以独特制剂方式充分发挥其清除HPV的作用。
Objective.To explore the effect and mechanism of Xinfuning（recombinant human α-2b interferon capsule for vaginal foams） on the clearance of human papilloma virus （HPV）. Methods.The patients with HPV infection were divided into experimental group （Xinfuning group） and control group （Shurunshuan group, a common recombinant human interferon α-2b in suppository form）. The HPV negative conversion rate was compared between the two groups after action on vaginal posterior fornix. The content of cytokines IL-4, IL-10, IFN-γ, TNF-α in the cervical region before or after the application was detected by EUSA. Results. The negative conversion rate in the experimental group was higher than that in the control group （P〈0.05）. The content of IL-4, IL-10 was decreased and the content of IFN-γ,TNF-α was incrased apparently（ P〈0.05）. Conclusions. Interferon has the effect on clearance of HPV infection by regulating Th1/rh2 balanced state to boost immunization and the unique preparation of Xinfuning can strengthen such function.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2009年第12期733-735,共3页
Journal of Practical Obstetrics and Gynecology
关键词
干扰素
人乳头状瘤病毒
转阴率
免疫
Interferon
Hurnan, papilloma virus
Negative conversion rate
Immune
