摘要
目的:探讨宫颈上皮内瘤变(CIN)治疗后高危型人乳头瘤病毒(HR-HPV)清除情况,评价HR-HPV检测在预测病变残留或复发中的意义。方法:对2008年10月01日至2009年12月30日在新疆自治区人民医院用第二代杂交捕获(HC2)法检测HR-HPV阳性,在阴道镜下活检诊断为CIN的90例患者进行宫颈锥切术,术后6,12,18,24个月分别行HR-HPV(检测)。对HR-HPV检测在预测病变残留或复发的价值进行回顾性分析。结果:CIN治疗后HR-HPV持续阳性人群病变残留或复发率达39.3%。HR-HPV阳性组与阴性组复发或残留有统计学意义(P<0.001)。HPV在预测锥切术后残留或复发的敏感性为100%,特异性为78.20%,阳性预测值为41.37%,阴性预测值为100%。结论:术后HR-HPV持续阳性提示病变残留或复发的可能性。对于术后HPV持续阳性者宜严密随访。
Objective： To approach the relationship of high risk（HR）-HPV detection and the outcomes of cervical intraepithelial neoplasm（CIN） after conization of cervix.Methods： A retrospective study was conducted on 90 women who underwent LEEP or CKC for CIN.HR-HPV positive hybrid captureⅡ method was used in all patients to detect viral load of HR-HPV respectively 6,12,18,24 months after treatment.Results： The residua or recurrence rate rate after conization among those HR-HPV persistent positive was 39.3%,and there was a significant difference in residua or recurrence between HR-HPV positive group and negative group after conization（P0.001）.The sensitivity,specificity,positive predictive value,and negative predictive value of high risk HPV-DNA test for the diagnosis of residual/recurrent was respectively 100%,78.20%,41.37%,and 100%.Conclusion： HPV infection after treatment suggests persistence or recurrence of the disease,and need to be followed closely.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2012年第4期528-531,共4页
Medical Journal of Wuhan University
基金
新疆维吾尔自治区自然科学基金资助项目(编号:2010211A55)
关键词
宫颈上皮内瘤变
宫颈锥切术
HPV持续感染
残留或复发
Cervical Intraepithelial Neoplasm
Conization
HPV Persistence Infection
Residua/Recurrence
