摘要
Rac及其下游靶蛋白p21活化激酶(PAK)均是最近新发现的多功能效应因子,与多种肿瘤的发生、发展密切相关。PAK主要通过其N端调节/黏附区的p21结合域(PBD)与上游调节器Rac相互作用从而使Rac/PAK信号通路激活,在结直肠癌的发生、发展、侵袭及转移中发挥重要的作用。随着研究的深入,越来越多的证据表明Rac/PAK信号通路不仅可以作为一种预测因子来判断结直肠癌的恶性进展及估计预后并且可能成为结直肠癌治疗的药物靶点,这些都为Rac/PAK信号通路应用于结直肠癌的诊疗提供了广阔的前景。
Rac and its downstream target proteins p-21 activated kinase （PAK） are multiftmctional effector which were discovered recently, have close connection with the occurrence and progression of various neoplasms. Through p21-binding domain （PBD） which at N-terminal＇s regulate/adhesion area, PAK interacts with the upstream regulator Rac so that Rac/PAK signaling pathway activation. It plays an important role in the occurrence, development, invasion and metastasis of colorectal cancer. With the deepening of the research, more and more evidence suggests that Rac/PAK signaling pathway can not only be judged as a predictor for malignant progression and prognosis of colorectal cancer, but also become a drug target for treatment of colorectal cancer, which have provided a broad prospect for application of Rac/PAK signal pathway in diagnosis and treatment of colorectal cancer.
出处
《中华临床医师杂志（电子版）》
CAS
2014年第1期108-111,共4页
Chinese Journal of Clinicians(Electronic Edition)
基金
山东省科技发展计划项目(2010g0021859)
山东省医学科学院院级科技计划青年基金(2013-45)
