摘要
通过测定小鼠炎症足组织中前列腺素E2 (PGE2 )和组胺的含量 ,以及胸膜炎大鼠胸腔渗出液中白细胞介素 1(IL - 1)、肿瘤坏死因子 (TNF)和磷脂酶A2 (PLA2 )的活性 ,发现给动物灌服辛夷挥发油对动物体内这四种炎症介质及磷脂酶A2 均有抑制作用 ,为辛夷油的抗炎效应提供了实验依据。
The quantity of prostaglandin E\-2(PGE\-2) and histamine in mice's swelling feet were measured. The activity of interleukin-1(IL-1) and tumour necrosis factor( TNF) and phospholipase A\-2(PLA\-2) were determined. The results showed that the volatile oil of Flos Magnoliae taken by experiment animals could inhibit those four inflammatory mediators and the activity of PLA\-2 in vivo. All the data reveal the anti-inflammatory mechanism of the oil.
