摘要
脂联素基因与2型糖尿病等代谢性疾病的发生相关,且受遗传背景和环境因素影响,遗传基因存在多态性,妊娠期糖尿病(GDM)与2型糖尿病在许多方面相似。通过检测、分析研究脂联素基因单核苷酸多态性对GDM母体并发症及围生儿结局的影响,对可能存在不同的GDM易患基因及基因多态性的研究提供新的视角,对调整现有GDM诊断标准及进行个性化的新的治疗方案提出可能依据,有着重要的临床意义。
Adiponectin genes are related to the etiological factors of some metabolic disorders such as type 2 diabetes, and they are affected by hereditary background and environmental factors. Due to genetic polymophism,there are similarities between gestational diabetes mellitus （GDM） and diabetes type 2. The aim of this study was to reveal the influence on the occurrence of maternal complications and perinatal outcomes in GDM,which might come from mononucleotide polymophism of aidponectin genes. It＇s a brand- new perspective and could provide evidences to further researches about the potential predisposing genes and genetic polymophism of GDM, and it is of great clinical significance in adjusting the diagnostic criteria and individual therapeutic strategies of GDM in the current stage.
出处
《医学综述》
2014年第5期870-872,共3页
Medical Recapitulate
关键词
脂联素基因
单核苷酸
多态性
妊娠期糖尿病
Adiponectin gene
Single nucleotide
Polymorphism
Gestational diabetes
