摘要
采用实时定量PCR技术研究汉族人群脂联素基因（apM1）多态性与2型糖尿病（DM）相关关系。发现apM12号外显子和内含子存在单核苷酸多态性（SNP），SNP45与2型DM密切相关，DM组T／T基因型明显高于肥胖组和对照组（均P〈0．01）。脂联素基因SNP45和SNP276与肥胖人群、无相关性。
Real-time PCR was performed to study the correlation between adiponectin gene polymorphism and type 2 diabetes mellitus （DM）. Single nucleotide polymorphism （SNP） in adiponectin gene were found in Chinese Han of Jinan district. SNP45 was closely correlated with type 2 DM, and the frequency of T/T genotype in type 2 diabetics was significanly higher than those in obese subjects and normal controls （ both P 〈 0.01 ）. No correlation was found in SNP45, SNP276 and obese subjects.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2007年第1期51-52,共2页
Chinese Journal of Endocrinology and Metabolism
关键词
脂联素
多态性
单核苷酸
糖尿病
2型
Adiponectin
Polymorphism, single nucleotide
Diabetes mellitus,type 2
