摘要
支气管哮喘是一种由多种细胞和细胞组分参与的气道慢性炎症性疾病,是全球范围内严重威胁公众健康的慢性疾病,其发病机制包括气道慢性炎症、气道高反应、不可逆性的气道重塑、神经反应、变态反应、遗传等等,多种机制之间相互关联、错综复杂,建立动物模型有助于研究其病因及发病机制。啮齿类动物模型是最常使用的支气管哮喘动物模型。该文主要通过对近年来不同种系的啮齿类实验动物在哮喘动物模型方面新研究的总结,为进一步开展哮喘相关研究提供帮助。
Bronchial asthma is a chronic airway inflammatory disease participated by many cells and cellular elements,which continues to be a major health problem worldwide. Its mechanism include chronic airway inflammation, airway hyperresponsiveness, airway remolding, nervous system, allergic reaction and genetic problems, and they react with each other forming complex correlation. Establishing animial models is helpful to the research of the etiology and pathogenesis. Rodents are the most popular bronchial asthma models. Here is to make a review of recent asthma animal modeling research at home and aboard, to contribute to the further research about asthma.
出处
《医学综述》
2014年第5期840-843,共4页
Medical Recapitulate
关键词
支气管哮喘
模型
动物
Bronchial asthma
Model
Animal
