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心脏缝隙连接蛋白基因变异与心房颤动 被引量：3

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摘要 心房颤动（房颤）是一种多因素疾病，大多数继发于严重的器质性心脏病或存在明确的危险因素；但也有2％～16％的房颤患者，无明显的已知危险因素和基础心脏病，称作特发性房颤或孤立性房颤，此类房颤多与遗传因素密切相关。然而，造成这种心律失常的始动因素和维持因素尚不明确，导致对此类房颤的预防和干预存在难度。随着分子生物学技术和细胞电生理技术的快速发展，房颤的分子遗传学病因研究取得了重大进展，为揭示房颤的发生、发展机制带来了曙光。
作者 沈虹 张红明 李艳敏
机构地区 济南军区总医院心内科
出处 《中华老年心脑血管病杂志》 CAS 北大核心 2014年第3期324-326,共3页 Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
关键词 心房颤动 连接蛋白类 基因型 多态性 单核苷酸 危险因素
分类号 R541.75 [医药卫生—心血管疾病]
  • 相关文献

参考文献28

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二级参考文献25

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共引文献12

同被引文献51

  • 1成永霞,钟国强.缝隙连接与心房颤动的折返机制[J].医学综述,2006,12(6):335-336. 被引量：3
  • 2侯月梅,张小琴,乔峻,林仁勇,木拉提,卢晓梅,陈艳.风湿性心脏病持续性心房颤动患者右心耳缝隙连接蛋白40和43mRNA水平的研究[J].中国心脏起搏与心电生理杂志,2006,20(3):274-274. 被引量：2
  • 3金奇,吴立群.心肌连接蛋白在心房颤动发生机制中的作用[J].诊断学理论与实践,2007,6(3):266-268. 被引量：1
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引证文献3

二级引证文献18

中华老年心脑血管病杂志
2014年 第3期

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