摘要
目的观察急性冠状动脉综合征不同类型患者血清纤维连接蛋白(Fn)水平的变化,探讨其在急性冠状动脉综合征发病中的作用和临床意义。方法急性冠状动脉综合征患者分为急性心肌梗死组50例、不稳定型心绞痛组17例,另设健康对照组13例,采用双抗体夹心固相酶联免疫吸附法测定血清Fn的水平。结果急性冠状动脉综合征组血清Fn的水平显著低于健康对照组[(233.38±119.15)μg/ml,(296.46±65.44)μg/ml,P<0.05];急性心肌梗死组与不稳定型心绞痛组血清Fn的水平差异无统计学意义。血清Fn的水平在不同的冠状动脉病变程度之间的差异无统计学意义[单支血管病变(226.83±112.35)μg/ml,双支病变(231.15±128.06)μg/ml及三支病变(277.32±139.61)μg/ml,F=0.825,P=0.445]。结论急性冠状动脉综合征患者血清Fn的水平显著低于健康对照组,与冠状动脉病变的程度无相关性。
Objective To investigate the changes of serum fibronectin（Fn）Level in patients with acute coronary syndrome （ACS）,and explore its roles in the pathogenesis of ACS.Methods ACS included unstable angina pectoris （UAP） and acute myocardial infarction （AMI）,17 patients presenting with UAP and 50 patients presenting with AMI were studied and 13 healthy volunteers served as control.Serum level of Fn was measured using enzyme link immunosorbent assay （ELISA）.Results The serum level of Fn in patient with ACS was lower than that in the control group（233.38±119.15μg/ml,296.46±65.44μg/ml,P0.05）.There was no significant difference in the serum levels of Fn between AMI group and the UAP group.No difference was found in the serum Fn levels among different CHD sub-groups（single-vessel,226.83 ±112.35μg/ml;double-vessel,231.15 ±128.06μg/ml;and triple-vessel disease,277.32 ±139.61μg/ml.F=0.825,P=0.445）.Conclusions The Serum Fn level in patient with ACS was lower than that in the control group,but there was no significant relationship between fibronectin and severity of disease.
出处
《中国临床保健杂志》
CAS
2010年第2期138-141,共4页
Chinese Journal of Clinical Healthcare
