摘要
目的:观察脐血输注对恶性肿瘤患者化疗后骨髓功能的保护作用。方法:90例患者随机分为治疗组和对照组,其中治疗组44例,对照组46例。治疗组当白细胞下降至度时开始静脉输注脐血,每天1～3单位,连用2～7d;在白细胞下降至度以下时加用造血细胞集落刺激因子(G-CSF),对照组在白细胞下降时不接受脐血输注,其他治疗同治疗组。结果:两组病人化疗后、度白细胞下降发生率分别为84.1%,50%和86.9%,52.1%,差异无显著意义(P>0.05);治疗组白细胞恢复正常所需时间为(7.4±3.5)d,短于对照组(11.5±4.3)d,差异有统计学意义(P<0.05)。输血反应发生率为1.3%。结论:本观察结果提示脐血输注未能明显地阻止白细胞的进一步下降,但可显著缩短白细胞恢复时间,表明脐血输注对化疗后的骨髓功能有良好的保护作用,而且脐血输注安全,值得推广。
Objective:To evaluate the effect of treating myelosuppression in cancer patients with cord blood Method:Cord bloods were administered for 2 to 7 doses for 44 patients when Ⅱ degree myelosuppression occured after combined chemotherapy in the treatment group Incidence rate of Ⅲ or Ⅳ degree of myelosuppression and recovery time of leukocyte were compared with the control group (n=46)Result:The incidence rate of Ⅲ or Ⅳ degree of myelosuppression were equivalent (P>0 05) in the two gruops Recovery time of leukocyte was (7 4±3 5) days in treatment group,which was significiently shorter than that of the control group(11 5±4 3) days (P<0 05) No severe transfusion reaction was observed Conclusion:Great benifit would be achieved to decurtate the recovery time of leukocyte as cord bloods were infused into patients with malignent solid tumor after chemotherapy
出处
《广西医科大学学报》
CAS
1999年第6期797-798,共2页
Journal of Guangxi Medical University
