不同剂量重组人类促红细胞生成素防治早产儿贫血的疗效观察被引量：36

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摘要目的　探讨重组人类促红细胞生成素 (rhEpo)治疗早产儿贫血的疗效及最适剂量。方法　予rhEpo75 0IU/ (kg·w) (Ⅰ组 )、6 0 0IU/ (kg·w) (Ⅱ组 )、45 0IU/ (kg·w) (Ⅲ组 )、30 0IU/ (kg·w) (Ⅳ组 ) ,分别治疗 15例胎龄 35周以下、出生体重 <180 0 g的早产儿 ,并与 15例同胎龄、同出生体重的早产儿 (Ⅴ组 )对照。结果　① 5组早产儿生后血红蛋白 (Hb)、红细胞压积比 (ΦRBC)均逐步下降 ,但Ⅰ组下降程度最轻 ,对照组下降程度最明显。治疗结束时 ,经方差分析 ,除了Ⅲ组与Ⅳ组之间无显著性差异外 ,其余各剂量组之间差异有显著性意义。②Ⅰ～Ⅳ组第 2周起网织红细胞 (Ret)较对照组升高 (P均 <0 0 1) ,并且与剂量有关 ;治疗结束时 ,各剂量组差异已不显著 ,但仍高于对照组 (P <0 0 1)。③Ⅰ～Ⅳ组第 2周血清铁明显低于对照组 ,第 4周更甚 ;治疗结束时 ,治疗组血清铁上升 ,但Ⅰ～Ⅲ组仍低于对照组 (P <0 0 1)。结论　rhEpo可提高Hb、ΦRBC及Ret,并且疗效与剂量有关 ,75 0IU/ (kg·w)

作者常立文刘皖君廖财绪赵锡慈

机构地区同济医科大学同济医院儿科

出处《中国实用儿科杂志》 CSCD 北大核心 2000年第12期740-742,共3页 Chinese Journal of Practical Pediatrics

关键词早产儿贫血重组人类促红细胞生成素剂量

分类号 R722.606 [医药卫生—儿科] R725.560.5 [医药卫生—儿科]

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1[1]Emmerson AJB,Coles Hjl,Stern CMM,et al.Double blind trial of recombinant human erythropoietin in preterm infants.Arch Dis Child,1993;68(3):291
2[2]Shannon KM,Keith ⅢJF，Mentzer WC,et al.Recombinant human erythropoietin stimulates erythropoiesis and reduces erythrocyte transfusions in very-low-birth-weight preterm infants.Pediatrics,1995;95(1):1
3[3]Messer J,Haddad J,Donato L,et al.Early treatment of premature infants with recombinant human erythropoietin.Pediatrics,1993;92(4):519
4[4]Soubasi V,Kremenopoulos G,Diamanti E,et al.Follow-up of very low-birth-weight infants after erythropoietin treatment to prevent anemia of prematurity.J Pediatr,1995;127(2):291
5[5]Carnielli V,Montini G,DaDioi R,et al.Effect of high doses of human recombinant erythropoietin on the need for blood transfusions in preterm infants.J Pediatr,1992;121(1):98
6[6]Shannon KM,Mentzer WC,Albels RI,et al.Recombinant human erythropoietin in the anemia of prematurity:results of a placebo controlled pilot study.J Pediatr,1991;118(6):949
7[7]Al-Kharfy A,Smyth JA,Wadsworth L,et al.Erythropoietin therapy in neonates at risk of having bronchopulmonary dysplasia and requiring multiple transfusions.J Pediatr,1996;129(1):89
8[8]Maier FF,Obladen M,Scigalla P,et al.The effect of epoetin beta(recombinant human erythopoietin)on the need for transfusion in very-low-birth-weight infants.N Engl J Med,1994;330(7):1173
9[9]Bechensteen AG,Haga P,Halvorsen S,et al.Effect of low and moderate doses of recombinant human erythropoietin on the haematological response in premature infant on a high protein and iron intake.Eur J Pediatr,1997;156(1):56