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中性粒-淋巴细胞比值与血小板参数在急性心肌梗死诊断中的应用价值 被引量：8

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摘要 目的探讨中性粒-淋巴细胞比值与血小板参数在急性心肌梗死(AMI)患者诊疗中的应用价值。方法测定55例AMI患者治疗前和治疗3天后、42例非AMI胸痛患者(胸痛对照组)和36例健康体检者(对照组)白细胞(WBC)、中性粒细胞(Neu)和淋巴细胞数(Ly)、血小板(PLT)、平均血小板体积(MPV)、血小板分布宽度(PDW)水平,计算Neu/Ly比值(NLR)和PLT/Ly比值(PLR)。同时计算各指标的诊断敏感性(Sen)、特异性(Spec)、阳性和阴性预测值(PV+和PV-)、阳性和阴性似然比(LR+和LR-),并以ROC曲线评价各指标的诊断效能。结果 AMI组治疗前NLR、WBC、MPV水平均显著高于胸痛组和对照组,PLT和PDW显著低于胸痛组和对照组,差异有统计学意义(P<0.01),胸痛组和对照组间各指标水平比较差异无统计学意义(P>0.05)。AMI死亡组治疗前NLR、WBC、PLR、MPV水平均显著升高而PDW显著降低,与AMI存活组比较,差异有统计学意义(P<0.01)。AMI存活组治疗后,除PLT外各指标水平均显著低于治疗前,差异有统计学意义(P<0.01)。NLR的Sen+Spec(159.80%)、PV++PV-(160.10%)和ROC曲线下面积(AUC=0.89)均最高,LR-(0.22)最低,其次是PLR。NLR的诊断临界值(cutoff值)为2.71,Sen为81.8,Spec为97.6。结论 NLR比血小板参数具有更高的诊断效能,是AMI诊断、疗效观察和预后判断的指标之一。
作者 马雅英 孙红 熊文翠 沈宇茜
机构地区 浙江省平湖市第一人民医院检验科
出处 《心脑血管病防治》 2014年第1期43-45,共3页 CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
关键词 急性心肌梗死 中性粒-淋巴细胞比值 血小板参数
分类号 R542.22 [医药卫生—心血管疾病]
  • 相关文献

参考文献8

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共引文献78

同被引文献64

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心脑血管病防治
2014年 第1期

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